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Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition.
Skidmore J, Atcha Z, Boucherat E, Castelletti L, Chen DW, Coppo FT, Cutler L, Dunsdon RM, Heath BM, Hutchings R, Hurst DN, Javed S, Martin S, Maskell ES, Norton D, Pemberton DJ, Redshaw S, Rutter R, Sehmi SS, Scoccitti T, Temple HE, Theobald P, Ward RW, Wilson DM. Skidmore J, et al. Among authors: atcha z. Bioorg Med Chem Lett. 2012 May 15;22(10):3560-3. doi: 10.1016/j.bmcl.2012.03.040. Epub 2012 Mar 16. Bioorg Med Chem Lett. 2012. PMID: 22503248
The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement.
Skidmore J, Atcha Z, Boucherat E, Castelletti L, Chen DW, Coppo FT, Cutler L, Dunsdon RM, Heath BM, Hutchings R, Hurst DN, Javed S, Martin S, Maskell ES, Norton D, Pemberton DJ, Redshaw S, Rutter R, Sehmi SS, Scoccitti T, Temple HE, Theobald P, Ward RW, Wilson DM. Skidmore J, et al. Among authors: atcha z. Bioorg Med Chem Lett. 2012 May 15;22(10):3531-4. doi: 10.1016/j.bmcl.2012.03.062. Epub 2012 Mar 21. Bioorg Med Chem Lett. 2012. PMID: 22503453
Cognitive enhancing effects of ghrelin receptor agonists.
Atcha Z, Chen WS, Ong AB, Wong FK, Neo A, Browne ER, Witherington J, Pemberton DJ. Atcha Z, et al. Psychopharmacology (Berl). 2009 Oct;206(3):415-27. doi: 10.1007/s00213-009-1620-6. Epub 2009 Aug 4. Psychopharmacology (Berl). 2009. PMID: 19652956
Alternative method of oral dosing for rats.
Atcha Z, Rourke C, Neo AH, Goh CW, Lim JS, Aw CC, Browne ER, Pemberton DJ. Atcha Z, et al. J Am Assoc Lab Anim Sci. 2010 May;49(3):335-43. J Am Assoc Lab Anim Sci. 2010. PMID: 20587166 Free PMC article.
Leptin and seasonal mammals.
Rousseau K, Atcha Z, Loudon AS. Rousseau K, et al. Among authors: atcha z. J Neuroendocrinol. 2003 Apr;15(4):409-14. doi: 10.1046/j.1365-2826.2003.01007.x. J Neuroendocrinol. 2003. PMID: 12622842 Review.
11 results