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NEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia: NEU1 restrains endothelial cell migration, whereas NEU3 does not.
Cross AS, Hyun SW, Miranda-Ribera A, Feng C, Liu A, Nguyen C, Zhang L, Luzina IG, Atamas SP, Twaddell WS, Guang W, Lillehoj EP, Puché AC, Huang W, Wang LX, Passaniti A, Goldblum SE. Cross AS, et al. Among authors: goldblum se. J Biol Chem. 2012 May 4;287(19):15966-80. doi: 10.1074/jbc.M112.346817. Epub 2012 Mar 8. J Biol Chem. 2012. PMID: 22403397 Free PMC article.
TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia.
Gong P, Angelini DJ, Yang S, Xia G, Cross AS, Mann D, Bannerman DD, Vogel SN, Goldblum SE. Gong P, et al. Among authors: goldblum se. J Biol Chem. 2008 May 9;283(19):13437-49. doi: 10.1074/jbc.M707986200. Epub 2008 Mar 7. J Biol Chem. 2008. PMID: 18326860 Free PMC article.
NEU1 sialidase expressed in human airway epithelia regulates epidermal growth factor receptor (EGFR) and MUC1 protein signaling.
Lillehoj EP, Hyun SW, Feng C, Zhang L, Liu A, Guang W, Nguyen C, Luzina IG, Atamas SP, Passaniti A, Twaddell WS, Puché AC, Wang LX, Cross AS, Goldblum SE. Lillehoj EP, et al. Among authors: goldblum se. J Biol Chem. 2012 Mar 9;287(11):8214-31. doi: 10.1074/jbc.M111.292888. Epub 2012 Jan 13. J Biol Chem. 2012. PMID: 22247545 Free PMC article.
TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia.
Liu A, Gong P, Hyun SW, Wang KZ, Cates EA, Perkins D, Bannerman DD, Puché AC, Toshchakov VY, Fang S, Auron PE, Vogel SN, Goldblum SE. Liu A, et al. Among authors: goldblum se. J Biol Chem. 2012 May 11;287(20):16132-45. doi: 10.1074/jbc.M111.310102. Epub 2012 Mar 23. J Biol Chem. 2012. PMID: 22447928 Free PMC article.
NEU1 sialidase regulates the sialylation state of CD31 and disrupts CD31-driven capillary-like tube formation in human lung microvascular endothelia.
Lee C, Liu A, Miranda-Ribera A, Hyun SW, Lillehoj EP, Cross AS, Passaniti A, Grimm PR, Kim BY, Welling PA, Madri JA, DeLisser HM, Goldblum SE. Lee C, et al. Among authors: goldblum se. J Biol Chem. 2014 Mar 28;289(13):9121-35. doi: 10.1074/jbc.M114.555888. Epub 2014 Feb 18. J Biol Chem. 2014. PMID: 24550400 Free PMC article.
Human airway epithelia express catalytically active NEU3 sialidase.
Lillehoj EP, Hyun SW, Feng C, Zhang L, Liu A, Guang W, Nguyen C, Sun W, Luzina IG, Webb TJ, Atamas SP, Passaniti A, Twaddell WS, Puché AC, Wang LX, Cross AS, Goldblum SE. Lillehoj EP, et al. Among authors: goldblum se. Am J Physiol Lung Cell Mol Physiol. 2014 May 1;306(9):L876-86. doi: 10.1152/ajplung.00322.2013. Epub 2014 Mar 21. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 24658138 Free PMC article.
Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis.
Luzina IG, Lockatell V, Hyun SW, Kopach P, Kang PH, Noor Z, Liu A, Lillehoj EP, Lee C, Miranda-Ribera A, Todd NW, Goldblum SE, Atamas SP. Luzina IG, et al. Among authors: goldblum se. Am J Physiol Lung Cell Mol Physiol. 2016 May 15;310(10):L940-54. doi: 10.1152/ajplung.00346.2015. Epub 2016 Mar 18. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 26993524 Free PMC article.
The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo.
Hyun SW, Liu A, Liu Z, Cross AS, Verceles AC, Magesh S, Kommagalla Y, Kona C, Ando H, Luzina IG, Atamas SP, Piepenbrink KH, Sundberg EJ, Guang W, Ishida H, Lillehoj EP, Goldblum SE. Hyun SW, et al. Among authors: goldblum se. Glycobiology. 2016 Aug;26(8):834-49. doi: 10.1093/glycob/cww060. Epub 2016 May 25. Glycobiology. 2016. PMID: 27226251 Free PMC article.
94 results