James MJ - Search Results

1

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.

Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA, Landreth GE. Cramer PE, et al. Among authors: james mj. Science. 2012 Mar 23;335(6075):1503-6. doi: 10.1126/science.1217697. Epub 2012 Feb 9. Science. 2012. PMID: 22323736 Free PMC article.

2

Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease.

Soper JH, Sugiyama S, Herbst-Robinson K, James MJ, Wang X, Trojanowski JQ, Smith AB 3rd, Lee VM, Ballatore C, Brunden KR. Soper JH, et al. Among authors: james mj. ACS Chem Neurosci. 2012 Nov 21;3(11):928-40. doi: 10.1021/cn3000795. Epub 2012 Jul 27. ACS Chem Neurosci. 2012. PMID: 23173073 Free PMC article.

3

Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors.

Herbst-Robinson KJ, Liu L, James M, Yao Y, Xie SX, Brunden KR. Herbst-Robinson KJ, et al. Sci Rep. 2015 Dec 17;5:18286. doi: 10.1038/srep18286. Sci Rep. 2015. PMID: 26672557 Free PMC article.

4

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.

Zhang B, Yao Y, Cornec AS, Oukoloff K, James MJ, Koivula P, Trojanowski JQ, Smith AB 3rd, Lee VM, Ballatore C, Brunden KR. Zhang B, et al. Among authors: james mj. Mol Neurodegener. 2018 Nov 7;13(1):59. doi: 10.1186/s13024-018-0291-3. Mol Neurodegener. 2018. PMID: 30404654 Free PMC article.

5

Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy.

Carroll JC, Iba M, Bangasser DA, Valentino RJ, James MJ, Brunden KR, Lee VM, Trojanowski JQ. Carroll JC, et al. Among authors: james mj. J Neurosci. 2011 Oct 5;31(40):14436-49. doi: 10.1523/JNEUROSCI.3836-11.2011. J Neurosci. 2011. PMID: 21976528 Free PMC article.

6

Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies.

Lou K, Yao Y, Hoye AT, James MJ, Cornec AS, Hyde E, Gay B, Lee VM, Trojanowski JQ, Smith AB 3rd, Brunden KR, Ballatore C. Lou K, et al. Among authors: james mj. J Med Chem. 2014 Jul 24;57(14):6116-27. doi: 10.1021/jm5005623. Epub 2014 Jul 3. J Med Chem. 2014. PMID: 24992153 Free PMC article.

7

Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies.

Kovalevich J, Cornec AS, Yao Y, James M, Crowe A, Lee VM, Trojanowski JQ, Smith AB 3rd, Ballatore C, Brunden KR. Kovalevich J, et al. J Pharmacol Exp Ther. 2016 May;357(2):432-50. doi: 10.1124/jpet.115.231175. Epub 2016 Mar 15. J Pharmacol Exp Ther. 2016. PMID: 26980057 Free PMC article.

8

Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation.

Crowe A, James MJ, Lee VM, Smith AB 3rd, Trojanowski JQ, Ballatore C, Brunden KR. Crowe A, et al. Among authors: james mj. J Biol Chem. 2013 Apr 19;288(16):11024-37. doi: 10.1074/jbc.M112.436006. Epub 2013 Feb 26. J Biol Chem. 2013. PMID: 23443659 Free PMC article.

9

Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.

Brunden KR, Zhang B, Carroll J, Yao Y, Potuzak JS, Hogan AM, Iba M, James MJ, Xie SX, Ballatore C, Smith AB 3rd, Lee VM, Trojanowski JQ. Brunden KR, et al. Among authors: james mj. J Neurosci. 2010 Oct 13;30(41):13861-6. doi: 10.1523/JNEUROSCI.3059-10.2010. J Neurosci. 2010. PMID: 20943926 Free PMC article.

10

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies.

Brunden KR, Yao Y, Potuzak JS, Ferrer NI, Ballatore C, James MJ, Hogan AM, Trojanowski JQ, Smith AB 3rd, Lee VM. Brunden KR, et al. Among authors: james mj. Pharmacol Res. 2011 Apr;63(4):341-51. doi: 10.1016/j.phrs.2010.12.002. Epub 2010 Dec 14. Pharmacol Res. 2011. PMID: 21163349 Free PMC article.

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