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Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy.
Carroll JC, Iba M, Bangasser DA, Valentino RJ, James MJ, Brunden KR, Lee VM, Trojanowski JQ. Carroll JC, et al. Among authors: brunden kr. J Neurosci. 2011 Oct 5;31(40):14436-49. doi: 10.1523/JNEUROSCI.3836-11.2011. J Neurosci. 2011. PMID: 21976528 Free PMC article.
Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies.
Lou K, Yao Y, Hoye AT, James MJ, Cornec AS, Hyde E, Gay B, Lee VM, Trojanowski JQ, Smith AB 3rd, Brunden KR, Ballatore C. Lou K, et al. Among authors: brunden kr. J Med Chem. 2014 Jul 24;57(14):6116-27. doi: 10.1021/jm5005623. Epub 2014 Jul 3. J Med Chem. 2014. PMID: 24992153 Free PMC article.
118 results