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The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H₂ receptor agonists.
J Med Chem. 2012 Feb 9;55(3):1147-60. doi: 10.1021/jm201128q. Epub 2012 Jan 25.
J Med Chem. 2012.
PMID: 22216892
Dimeric carbamoylguanidine-type histamine H2 receptor ligands: A new class of potent and selective agonists.
Kagermeier N, Werner K, Keller M, Baumeister P, Bernhardt G, Seifert R, Buschauer A.
Kagermeier N, et al.
Bioorg Med Chem. 2015 Jul 15;23(14):3957-69. doi: 10.1016/j.bmc.2015.01.012. Epub 2015 Jan 14.
Bioorg Med Chem. 2015.
PMID: 25639885
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[(3) H]UR-DE257: development of a tritium-labeled squaramide-type selective histamine H2 receptor antagonist.
Baumeister P, Erdmann D, Biselli S, Kagermeier N, Elz S, Bernhardt G, Buschauer A.
Baumeister P, et al. Among authors: kagermeier n.
ChemMedChem. 2015 Jan;10(1):83-93. doi: 10.1002/cmdc.201402344. Epub 2014 Oct 15.
ChemMedChem. 2015.
PMID: 25320025
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