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Small-molecule synergist of the Wnt/beta-catenin signaling pathway.
Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S. Zhang Q, et al. Among authors: major mb. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7444-8. doi: 10.1073/pnas.0702136104. Epub 2007 Apr 25. Proc Natl Acad Sci U S A. 2007. PMID: 17460038 Free PMC article.
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.
De Ferrari GV, Papassotiropoulos A, Biechele T, Wavrant De-Vrieze F, Avila ME, Major MB, Myers A, Sáez K, Henríquez JP, Zhao A, Wollmer MA, Nitsch RM, Hock C, Morris CM, Hardy J, Moon RT. De Ferrari GV, et al. Among authors: major mb. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9434-9. doi: 10.1073/pnas.0603523104. Epub 2007 May 21. Proc Natl Acad Sci U S A. 2007. PMID: 17517621 Free PMC article.
Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model.
Chien AJ, Moore EC, Lonsdorf AS, Kulikauskas RM, Rothberg BG, Berger AJ, Major MB, Hwang ST, Rimm DL, Moon RT. Chien AJ, et al. Among authors: major mb. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1193-8. doi: 10.1073/pnas.0811902106. Epub 2009 Jan 14. Proc Natl Acad Sci U S A. 2009. PMID: 19144919 Free PMC article.
Beta-catenin gets jaded and von Hippel-Lindau is to blame.
Berndt JD, Moon RT, Major MB. Berndt JD, et al. Among authors: major mb. Trends Biochem Sci. 2009 Mar;34(3):101-4. doi: 10.1016/j.tibs.2008.12.002. Epub 2009 Feb 11. Trends Biochem Sci. 2009. PMID: 19217300
"Omic" risk assessment.
Major MB, Moon RT. Major MB, et al. Sci Signal. 2009 May 26;2(72):eg7. doi: 10.1126/scisignal.272eg7. Sci Signal. 2009. PMID: 19471021
92 results