Gribkoff VK - Search Results

1

The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis.

Cudkowicz M, Bozik ME, Ingersoll EW, Miller R, Mitsumoto H, Shefner J, Moore DH, Schoenfeld D, Mather JL, Archibald D, Sullivan M, Amburgey C, Moritz J, Gribkoff VK. Cudkowicz M, et al. Among authors: gribkoff vk. Nat Med. 2011 Nov 20;17(12):1652-6. doi: 10.1038/nm.2579. Nat Med. 2011. PMID: 22101764 Clinical Trial.

2

KNS-760704 [(6R)-4,5,6,7-tetrahydro-N6-propyl-2, 6-benzothiazole-diamine dihydrochloride monohydrate] for the treatment of amyotrophic lateral sclerosis.

Gribkoff VK, Bozik ME. Gribkoff VK, et al. CNS Neurosci Ther. 2008 Fall;14(3):215-26. doi: 10.1111/j.1755-5949.2008.00048.x. CNS Neurosci Ther. 2008. PMID: 18801114 Free PMC article. Review.

3

Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects.

Bozik ME, Mather JL, Kramer WG, Gribkoff VK, Ingersoll EW. Bozik ME, et al. Among authors: gribkoff vk. J Clin Pharmacol. 2011 Aug;51(8):1177-85. doi: 10.1177/0091270010379412. Epub 2010 Oct 19. J Clin Pharmacol. 2011. PMID: 20959524 Clinical Trial.

4

The mitochondrial complex V-associated large-conductance inner membrane current is regulated by cyclosporine and dexpramipexole.

Alavian KN, Dworetzky SI, Bonanni L, Zhang P, Sacchetti S, Li H, Signore AP, Smith PJ, Gribkoff VK, Jonas EA. Alavian KN, et al. Among authors: gribkoff vk. Mol Pharmacol. 2015 Jan;87(1):1-8. doi: 10.1124/mol.114.095661. Epub 2014 Oct 20. Mol Pharmacol. 2015. PMID: 25332381 Free PMC article.

5

The therapeutic potential of neuronal K V 7 (KCNQ) channel modulators: an update.

Gribkoff VK. Gribkoff VK. Expert Opin Ther Targets. 2008 May;12(5):565-81. doi: 10.1517/14728222.12.5.565. Expert Opin Ther Targets. 2008. PMID: 18410240 Review.

6

The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes.

Gribkoff VK, Kaczmarek LK. Gribkoff VK, et al. Neuropharmacology. 2017 Jul 1;120:11-19. doi: 10.1016/j.neuropharm.2016.03.021. Epub 2016 Mar 12. Neuropharmacology. 2017. PMID: 26979921 Free PMC article. Review.

7

Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency.

Alavian KN, Dworetzky SI, Bonanni L, Zhang P, Sacchetti S, Mariggio MA, Onofrj M, Thomas A, Li H, Mangold JE, Signore AP, Demarco U, Demady DR, Nabili P, Lazrove E, Smith PJ, Gribkoff VK, Jonas EA. Alavian KN, et al. Among authors: gribkoff vk. Brain Res. 2012 Mar 29;1446:1-11. doi: 10.1016/j.brainres.2012.01.046. Epub 2012 Jan 28. Brain Res. 2012. PMID: 22364637 Free PMC article.

8

Effects of channel modulators on cloned large-conductance calcium-activated potassium channels.

Gribkoff VK, Lum-Ragan JT, Boissard CG, Post-Munson DJ, Meanwell NA, Starrett JE Jr, Kozlowski ES, Romine JL, Trojnacki JT, Mckay MC, Zhong J, Dworetzky SI. Gribkoff VK, et al. Mol Pharmacol. 1996 Jul;50(1):206-17. Mol Pharmacol. 1996. PMID: 8700114

9

The pharmacology and molecular biology of large-conductance calcium-activated (BK) potassium channels.

Gribkoff VK, Starrett JE Jr, Dworetzky SI. Gribkoff VK, et al. Adv Pharmacol. 1997;37:319-48. doi: 10.1016/s1054-3589(08)60954-0. Adv Pharmacol. 1997. PMID: 8891106 Review. No abstract available.

10

Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.

Joiner WJ, Tang MD, Wang LY, Dworetzky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK. Joiner WJ, et al. Among authors: gribkoff vk. Nat Neurosci. 1998 Oct;1(6):462-9. doi: 10.1038/2176. Nat Neurosci. 1998. PMID: 10196543

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