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A molecular basis of analgesic tolerance to cannabinoids.
Tappe-Theodor A, Agarwal N, Katona I, Rubino T, Martini L, Swiercz J, Mackie K, Monyer H, Parolaro D, Whistler J, Kuner T, Kuner R. Tappe-Theodor A, et al. J Neurosci. 2007 Apr 11;27(15):4165-77. doi: 10.1523/JNEUROSCI.5648-06.2007. J Neurosci. 2007. PMID: 17428994 Free PMC article.
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.
Luo C, Gangadharan V, Bali KK, Xie RG, Agarwal N, Kurejova M, Tappe-Theodor A, Tegeder I, Feil S, Lewin G, Polgar E, Todd AJ, Schlossmann J, Hofmann F, Liu DL, Hu SJ, Feil R, Kuner T, Kuner R. Luo C, et al. PLoS Biol. 2012;10(3):e1001283. doi: 10.1371/journal.pbio.1001283. Epub 2012 Mar 13. PLoS Biol. 2012. PMID: 22427743 Free PMC article.
A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signalling pathways in sensory nerves in vivo.
Gangadharan V, Selvaraj D, Kurejova M, Njoo C, Gritsch S, Škoricová D, Horstmann H, Offermanns S, Brown AJ, Kuner T, Tappe-Theodor A, Kuner R. Gangadharan V, et al. Pain. 2013 Dec;154(12):2801-2812. doi: 10.1016/j.pain.2013.08.019. Epub 2013 Aug 22. Pain. 2013. PMID: 23973358
GABA blocks pathological but not acute TRPV1 pain signals.
Hanack C, Moroni M, Lima WC, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A, Wetzel C, Kuich PH, Gassmann M, Roggenkamp D, Bettler B, Lewin GR, Selbach M, Siemens J. Hanack C, et al. Cell. 2015 Feb 12;160(4):759-770. doi: 10.1016/j.cell.2015.01.022. Cell. 2015. PMID: 25679765 Free article.
30 results