Ryckmans T - Search Results

1

Application of Barluenga Boronic Coupling (BBC) to the parallel synthesis of drug-like and drug fragment-like molecules.

Nakagawa S, Bainbridge KA, Butcher K, Ellis D, Klute W, Ryckmans T. Nakagawa S, et al. Among authors: ryckmans t. ChemMedChem. 2012 Feb 6;7(2):233-6. doi: 10.1002/cmdc.201100339. Epub 2011 Nov 7. ChemMedChem. 2012. PMID: 22065646 No abstract available.

2

Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis.

Ryckmans T, Edwards MP, Horne VA, Correia AM, Owen DR, Thompson LR, Tran I, Tutt MF, Young T. Ryckmans T, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4406-9. doi: 10.1016/j.bmcl.2009.05.062. Epub 2009 May 21. Bioorg Med Chem Lett. 2009. PMID: 19500981

3

2,4-Diaminopyridine delta-opioid receptor agonists and their associated hERG pharmacology.

Owen DR, Rodriguez-Lens M, Corless MD, Gaulier SM, Horne VA, Kinloch RA, Maw GN, Pearce DW, Rees H, Ringer TJ, Ryckmans T, Stammen BL. Owen DR, et al. Among authors: ryckmans t. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1702-6. doi: 10.1016/j.bmcl.2009.01.106. Epub 2009 Feb 5. Bioorg Med Chem Lett. 2009. PMID: 19231185

4

Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability.

Johnson PS, Ryckmans T, Bryans J, Beal DM, Dack KN, Feeder N, Harrison A, Lewis M, Mason HJ, Mills J, Newman J, Pasquinet C, Rawson DJ, Roberts LR, Russell R, Spark D, Stobie A, Underwood TJ, Ward R, Wheeler S. Johnson PS, et al. Among authors: ryckmans t. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5684-7. doi: 10.1016/j.bmcl.2011.08.038. Epub 2011 Aug 12. Bioorg Med Chem Lett. 2011. PMID: 21885275

5

Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.

Fish PV, Deur C, Gan X, Greene K, Hoople D, Mackenny M, Para KS, Reeves K, Ryckmans T, Stiff C, Stobie A, Wakenhut F, Whitlock GA. Fish PV, et al. Among authors: ryckmans t. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2562-6. doi: 10.1016/j.bmcl.2008.03.050. Epub 2008 Mar 20. Bioorg Med Chem Lett. 2008. PMID: 18387300

6

Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.

Ryckmans T, Aubdool AA, Bodkin JV, Cox P, Brain SD, Dupont T, Fairman E, Hashizume Y, Ishii N, Kato T, Kitching L, Newman J, Omoto K, Rawson D, Strover J. Ryckmans T, et al. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-9. doi: 10.1016/j.bmcl.2011.06.035. Epub 2011 Jun 21. Bioorg Med Chem Lett. 2011. PMID: 21741838

7

N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.

Wakenhut F, Allan GA, Fish PV, Fray MJ, Harrison AC, McCoy R, Phillips SC, Ryckmans T, Stobie A, Westbrook D, Westbrook SL, Whitlock GA. Wakenhut F, et al. Among authors: ryckmans t. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5078-81. doi: 10.1016/j.bmcl.2009.07.049. Epub 2009 Jul 31. Bioorg Med Chem Lett. 2009. PMID: 19647430

8

Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.

Fish PV, Wakenhut F, Ryckmans T, Stobie A. Fish PV, et al. Among authors: ryckmans t. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4579-83. doi: 10.1016/j.bmcl.2009.06.096. Epub 2009 Jul 2. Bioorg Med Chem Lett. 2009. PMID: 19616432

9

Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.

Fish PV, Barta NS, Gray DL, Ryckmans T, Stobie A, Wakenhut F, Whitlock GA. Fish PV, et al. Among authors: ryckmans t. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4355-9. doi: 10.1016/j.bmcl.2008.06.071. Epub 2008 Jun 25. Bioorg Med Chem Lett. 2008. PMID: 18621528

10

TAK1 inhibition in the DFG-out conformation.

Kilty I, Green MP, Bell AS, Brown DG, Dodd PG, Hewson C, Hughes SJ, Phillips C, Ryckmans T, Smith RT, van Hoorn WP, Cohen P, Jones LH. Kilty I, et al. Among authors: ryckmans t. Chem Biol Drug Des. 2013 Nov;82(5):500-5. doi: 10.1111/cbdd.12169. Chem Biol Drug Des. 2013. PMID: 23745990

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