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High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6.
Zhang L, Lim SL, Du H, Zhang M, Kozak I, Hannum G, Wang X, Ouyang H, Hughes G, Zhao L, Zhu X, Lee C, Su Z, Zhou X, Shaw R, Geum D, Wei X, Zhu J, Ideker T, Oka C, Wang N, Yang Z, Shaw PX, Zhang K. Zhang L, et al. Among authors: oka c. J Biol Chem. 2012 Jan 6;287(2):1520-6. doi: 10.1074/jbc.M111.275990. Epub 2011 Nov 2. J Biol Chem. 2012. PMID: 22049084 Free PMC article. Clinical Trial.
HTRA1 (high temperature requirement A serine peptidase 1) gene is transcriptionally regulated by insertion/deletion nucleotides located at the 3' end of the ARMS2 (age-related maculopathy susceptibility 2) gene in patients with age-related macular degeneration.
Iejima D, Itabashi T, Kawamura Y, Noda T, Yuasa S, Fukuda K, Oka C, Iwata T. Iejima D, et al. Among authors: oka c. J Biol Chem. 2015 Jan 30;290(5):2784-97. doi: 10.1074/jbc.M114.593384. Epub 2014 Dec 17. J Biol Chem. 2015. PMID: 25519903 Free PMC article.
Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice.
Jones A, Kumar S, Zhang N, Tong Z, Yang JH, Watt C, Anderson J, Amrita, Fillerup H, McCloskey M, Luo L, Yang Z, Ambati B, Marc R, Oka C, Zhang K, Fu Y. Jones A, et al. Among authors: oka c. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14578-83. doi: 10.1073/pnas.1102853108. Epub 2011 Aug 15. Proc Natl Acad Sci U S A. 2011. PMID: 21844367 Free PMC article.
Abnormal development of placenta in HtrA1-deficient mice.
Hasan MZ, Ikawati M, Tocharus J, Kawaichi M, Oka C. Hasan MZ, et al. Among authors: oka c. Dev Biol. 2015 Jan 1;397(1):89-102. doi: 10.1016/j.ydbio.2014.10.015. Epub 2014 Oct 27. Dev Biol. 2015. PMID: 25446274 Free article.
CADASIL brain vessels show a HTRA1 loss-of-function profile.
Zellner A, Scharrer E, Arzberger T, Oka C, Domenga-Denier V, Joutel A, Lichtenthaler SF, Müller SA, Dichgans M, Haffner C. Zellner A, et al. Among authors: oka c. Acta Neuropathol. 2018 Jul;136(1):111-125. doi: 10.1007/s00401-018-1853-8. Epub 2018 May 3. Acta Neuropathol. 2018. PMID: 29725820
89 results