Brown AD - Search Results

1

Discovery of potent, metabolically stable purine CRF-1 antagonists with differentiated binding kinetic profiles.

Miller DC, Klute W, Brown AD. Miller DC, et al. Among authors: brown ad. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6108-11. doi: 10.1016/j.bmcl.2011.08.040. Epub 2011 Aug 16. Bioorg Med Chem Lett. 2011. PMID: 21889333

2

Serendipity in drug-discovery: a new series of 2-(benzyloxy)benzamides as TRPM8 antagonists.

Brown A, Ellis D, Favor DA, Kirkup T, Klute W, MacKenny M, McMurray G, Stennett A. Brown A, et al. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6118-22. doi: 10.1016/j.bmcl.2013.09.016. Epub 2013 Sep 19. Bioorg Med Chem Lett. 2013. PMID: 24080460

3

Optimising metabolic stability in lipophilic chemical space: the identification of a metabolically stable pyrazolopyrimidine CRF-1 receptor antagonist.

Miller DC, Klute W, Calabrese A, Brown AD. Miller DC, et al. Among authors: brown ad. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6144-7. doi: 10.1016/j.bmcl.2009.09.016. Epub 2009 Sep 11. Bioorg Med Chem Lett. 2009. PMID: 19782566

4

The discovery and optimization of benzimidazoles as selective Na_V1.8 blockers for the treatment of pain.

Brown AD, Bagal SK, Blackwell P, Blakemore DC, Brown B, Bungay PJ, Corless M, Crawforth J, Fengas D, Fenwick DR, Gray V, Kemp M, Klute W, Malet Sanz L, Miller D, Murata Y, Payne CE, Skerratt S, Stevens EB, Warmus JS. Brown AD, et al. Among authors: brown b. Bioorg Med Chem. 2019 Jan 1;27(1):230-239. doi: 10.1016/j.bmc.2018.12.002. Epub 2018 Dec 4. Bioorg Med Chem. 2019. PMID: 30538065

5

Design and optimization of potent, selective antagonists of Oxytocin.

Brown A, Brown L, Ellis D, Puhalo N, Smith CR, Wallace O, Watson L. Brown A, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4278-81. doi: 10.1016/j.bmcl.2008.06.098. Epub 2008 Jul 3. Bioorg Med Chem Lett. 2008. PMID: 18639455

6

Highly potent and selective Na_V1.7 inhibitors for use as intravenous agents and chemical probes.

Storer RI, Pike A, Swain NA, Alexandrou AJ, Bechle BM, Blakemore DC, Brown AD, Castle NA, Corbett MS, Flanagan NJ, Fengas D, Johnson MS, Jones LH, Marron BE, Payne CE, Printzenhoff D, Rawson DJ, Rose CR, Ryckmans T, Sun J, Theile JW, Torella R, Tseng E, Warmus JS. Storer RI, et al. Among authors: brown ad. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4805-4811. doi: 10.1016/j.bmcl.2017.09.056. Epub 2017 Sep 28. Bioorg Med Chem Lett. 2017. PMID: 29029933

7

Sulfonamides as selective oestrogen receptor β agonists.

Roberts LR, Armor D, Barker C, Bent A, Bess K, Brown A, Favor DA, Ellis D, Irving SL, MacKenny M, Phillips C, Pullen N, Stennett A, Strand L, Styles M. Roberts LR, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5680-3. doi: 10.1016/j.bmcl.2011.08.041. Epub 2011 Aug 16. Bioorg Med Chem Lett. 2011. PMID: 21885279

8

Triazole oxytocin antagonists: identification of aryl ether replacements for a biaryl substituent.

Brown A, Brown L, Brown TB, Calabrese A, Ellis D, Puhalo N, Smith CR, Wallace O, Watson L. Brown A, et al. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5242-4. doi: 10.1016/j.bmcl.2008.08.066. Epub 2008 Aug 22. Bioorg Med Chem Lett. 2008. PMID: 18778939

9

Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent.

Brown A, Brown TB, Calabrese A, Ellis D, Puhalo N, Ralph M, Watson L. Brown A, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):516-20. doi: 10.1016/j.bmcl.2009.11.097. Epub 2009 Nov 23. Bioorg Med Chem Lett. 2010. PMID: 19963374

10

Identification of amide bioisosteres of triazole oxytocin antagonists.

Brown A, Ellis D, Wallace O, Ralph M. Brown A, et al. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2224-8. doi: 10.1016/j.bmcl.2010.02.018. Epub 2010 Feb 8. Bioorg Med Chem Lett. 2010. PMID: 20189387

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