Schepmann D - Search Results

1

Synthesis and in vitro Evaluation of Novel Indole-Based Sigma Receptors Ligands.

Yarim M, Koksal M, Schepmann D, Wünsch B. Yarim M, et al. Among authors: schepmann d. Chem Biol Drug Des. 2011 Nov;78(5):869-75. doi: 10.1111/j.1747-0285.2011.01215.x. Epub 2011 Sep 26. Chem Biol Drug Des. 2011. PMID: 21848665

2

The sigma enigma: in vitro/in silico site-directed mutagenesis studies unveil σ1 receptor ligand binding.

Brune S, Schepmann D, Klempnauer KH, Marson D, Dal Col V, Laurini E, Fermeglia M, Wünsch B, Pricl S. Brune S, et al. Among authors: schepmann d. Biochemistry. 2014 May 13;53(18):2993-3003. doi: 10.1021/bi401575g. Epub 2014 Apr 28. Biochemistry. 2014. PMID: 24766040

3

Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease.

Turgutalp B, Bhattarai P, Ercetin T, Luise C, Reis R, Gurdal EE, Isaak A, Biriken D, Dinter E, Sipahi H, Schepmann D, Junker A, Wünsch B, Sippl W, Gulcan HO, Kizil C, Yarim M. Turgutalp B, et al. Among authors: schepmann d. J Med Chem. 2022 Sep 22;65(18):12292-12318. doi: 10.1021/acs.jmedchem.2c01003. Epub 2022 Sep 9. J Med Chem. 2022. PMID: 36084304

4

Synthesis of bicyclic sigma receptor ligands with cytotoxic activity.

Geiger C, Zelenka C, Weigl M, Fröhlich R, Wibbeling B, Lehmkuhl K, Schepmann D, Grünert R, Bednarski PJ, Wünsch B. Geiger C, et al. Among authors: schepmann d. J Med Chem. 2007 Nov 29;50(24):6144-53. doi: 10.1021/jm070620b. Epub 2007 Oct 30. J Med Chem. 2007. PMID: 17967001

5

Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure.

Schläger T, Schepmann D, Würthwein EU, Wünsch B. Schläger T, et al. Among authors: schepmann d. Bioorg Med Chem. 2008 Mar 15;16(6):2992-3001. doi: 10.1016/j.bmc.2007.12.045. Epub 2007 Dec 25. Bioorg Med Chem. 2008. PMID: 18221879

6

Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2).

Rossi D, Urbano M, Pedrali A, Serra M, Zampieri D, Mamolo MG, Laggner C, Zanette C, Florio C, Schepmann D, Wuensch B, Azzolina O, Collina S. Rossi D, et al. Among authors: schepmann d. Bioorg Med Chem. 2010 Feb;18(3):1204-12. doi: 10.1016/j.bmc.2009.12.039. Epub 2009 Dec 21. Bioorg Med Chem. 2010. PMID: 20045339

7

Synthesis, pharmacological evaluation, and σ1 receptor interaction analysis of hydroxyethyl substituted piperazines.

Weber F, Brune S, Korpis K, Bednarski PJ, Laurini E, Dal Col V, Pricl S, Schepmann D, Wünsch B. Weber F, et al. Among authors: schepmann d. J Med Chem. 2014 Apr 10;57(7):2884-94. doi: 10.1021/jm401707t. Epub 2014 Mar 27. J Med Chem. 2014. PMID: 24617836

8

Improving selectivity preserving affinity: new piperidine-4-carboxamide derivatives as effective sigma-1-ligands.

Zampieri D, Laurini E, Vio L, Fermeglia M, Pricl S, Wünsch B, Schepmann D, Mamolo MG. Zampieri D, et al. Among authors: schepmann d. Eur J Med Chem. 2015 Jan 27;90:797-808. doi: 10.1016/j.ejmech.2014.12.018. Epub 2014 Dec 12. Eur J Med Chem. 2015. PMID: 25528334 Free article.

9

Rigidity versus Flexibility: Is This an Issue in σ1 Receptor Ligand Affinity and Activity?

Weber F, Brune S, Börgel F, Lange C, Korpis K, Bednarski PJ, Laurini E, Fermeglia M, Pricl S, Schepmann D, Wünsch B. Weber F, et al. Among authors: schepmann d. J Med Chem. 2016 Jun 9;59(11):5505-19. doi: 10.1021/acs.jmedchem.6b00585. Epub 2016 May 23. J Med Chem. 2016. PMID: 27156565 Free article.

10

Computer-assisted design, synthesis, binding and cytotoxicity assessments of new 1-(4-(aryl(methyl)amino)butyl)-heterocyclic sigma 1 ligands.

Zampieri D, Vio L, Fermeglia M, Pricl S, Wünsch B, Schepmann D, Romano M, Mamolo MG, Laurini E. Zampieri D, et al. Among authors: schepmann d. Eur J Med Chem. 2016 Oct 4;121:712-726. doi: 10.1016/j.ejmech.2016.06.001. Epub 2016 Jun 3. Eur J Med Chem. 2016. PMID: 27366902 Free article.

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