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Conformation determines the seeding potencies of native and recombinant Tau aggregates.
Falcon B, Cavallini A, Angers R, Glover S, Murray TK, Barnham L, Jackson S, O'Neill MJ, Isaacs AM, Hutton ML, Szekeres PG, Goedert M, Bose S. Falcon B, et al. Among authors: hutton ml. J Biol Chem. 2015 Jan 9;290(2):1049-65. doi: 10.1074/jbc.M114.589309. Epub 2014 Nov 18. J Biol Chem. 2015. PMID: 25406315 Free PMC article.
A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.
Ahmed Z, Cooper J, Murray TK, Garn K, McNaughton E, Clarke H, Parhizkar S, Ward MA, Cavallini A, Jackson S, Bose S, Clavaguera F, Tolnay M, Lavenir I, Goedert M, Hutton ML, O'Neill MJ. Ahmed Z, et al. Among authors: hutton ml. Acta Neuropathol. 2014 May;127(5):667-83. doi: 10.1007/s00401-014-1254-6. Epub 2014 Feb 16. Acta Neuropathol. 2014. PMID: 24531916 Free PMC article.
Astrocytes and neuroinflammation in Alzheimer's disease.
Phillips EC, Croft CL, Kurbatskaya K, O'Neill MJ, Hutton ML, Hanger DP, Garwood CJ, Noble W. Phillips EC, et al. Among authors: hutton ml. Biochem Soc Trans. 2014 Oct;42(5):1321-5. doi: 10.1042/BST20140155. Biochem Soc Trans. 2014. PMID: 25233410
Imbalance in the response of pre- and post-synaptic components to amyloidopathy.
Stephen TL, Tamagnini F, Piegsa J, Sung K, Harvey J, Oliver-Evans A, Murray TK, Ahmed Z, Hutton ML, Randall A, O'Neill MJ, Jackson JS. Stephen TL, et al. Among authors: hutton ml. Sci Rep. 2019 Oct 16;9(1):14837. doi: 10.1038/s41598-019-50781-1. Sci Rep. 2019. PMID: 31619689 Free PMC article.
Metabotropic Glutamate Receptors Modulate Exocytotic Tau Release and Propagation.
Mazzo F, Butnaru I, Grubisha O, Ficulle E, Sanger H, Fitzgerald G, Pan F, Pasqui F, Murray T, Monn J, Li X, Hutton M, Bose S, Schiavo G, Sher E. Mazzo F, et al. J Pharmacol Exp Ther. 2022 Nov;383(2):117-128. doi: 10.1124/jpet.122.001307. Epub 2022 Sep 18. J Pharmacol Exp Ther. 2022. PMID: 36116796
276 results