Zajac E - Search Results

1

Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation.

Bekes EM, Schweighofer B, Kupriyanova TA, Zajac E, Ardi VC, Quigley JP, Deryugina EI. Bekes EM, et al. Among authors: zajac e. Am J Pathol. 2011 Sep;179(3):1455-70. doi: 10.1016/j.ajpath.2011.05.031. Epub 2011 Jul 8. Am J Pathol. 2011. PMID: 21741942 Free PMC article.

2

Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells.

Bekes EM, Deryugina EI, Kupriyanova TA, Zajac E, Botkjaer KA, Andreasen PA, Quigley JP. Bekes EM, et al. Among authors: zajac e. Neoplasia. 2011 Sep;13(9):806-21. doi: 10.1593/neo.11704. Neoplasia. 2011. PMID: 21969814 Free PMC article.

3

Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination.

Juncker-Jensen A, Deryugina EI, Rimann I, Zajac E, Kupriyanova TA, Engelholm LH, Quigley JP. Juncker-Jensen A, et al. Among authors: zajac e. Cancer Res. 2013 Jul 15;73(14):4196-211. doi: 10.1158/0008-5472.CAN-12-4495. Epub 2013 May 16. Cancer Res. 2013. PMID: 23687338 Free PMC article.

4

Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9.

Zajac E, Schweighofer B, Kupriyanova TA, Juncker-Jensen A, Minder P, Quigley JP, Deryugina EI. Zajac E, et al. Blood. 2013 Dec 12;122(25):4054-67. doi: 10.1182/blood-2013-05-501494. Epub 2013 Oct 30. Blood. 2013. PMID: 24174628 Free PMC article. Clinical Trial.

5

Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment.

Deryugina EI, Zajac E, Juncker-Jensen A, Kupriyanova TA, Welter L, Quigley JP. Deryugina EI, et al. Among authors: zajac e. Neoplasia. 2014 Oct 23;16(10):771-88. doi: 10.1016/j.neo.2014.08.013. eCollection 2014 Oct. Neoplasia. 2014. PMID: 25379015 Free PMC article.

6

EGFR regulates the development and microarchitecture of intratumoral angiogenic vasculature capable of sustaining cancer cell intravasation.

Minder P, Zajac E, Quigley JP, Deryugina EI. Minder P, et al. Among authors: zajac e. Neoplasia. 2015 Aug;17(8):634-49. doi: 10.1016/j.neo.2015.08.002. Neoplasia. 2015. PMID: 26408256 Free PMC article.

7

Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1.

Vandooren J, Born B, Solomonov I, Zajac E, Saldova R, Senske M, Ugarte-Berzal E, Martens E, Van den Steen PE, Van Damme J, Garcia-Pardo A, Froeyen M, Deryugina EI, Quigley JP, Moestrup SK, Rudd PM, Sagi I, Opdenakker G. Vandooren J, et al. Among authors: zajac e. Biochem J. 2015 Jan 15;465(2):259-70. doi: 10.1042/BJ20140418. Biochem J. 2015. PMID: 25360794 Free PMC article.

8

LTBP3 promotes early metastatic events during cancer cell dissemination.

Deryugina EI, Zajac E, Zilberberg L, Muramatsu T, Joshi G, Dabovic B, Rifkin D, Quigley JP. Deryugina EI, et al. Among authors: zajac e. Oncogene. 2018 Apr;37(14):1815-1829. doi: 10.1038/s41388-017-0075-1. Epub 2018 Jan 19. Oncogene. 2018. PMID: 29348457 Free PMC article.

9

Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin.

Singhal SS, Yadav S, Singhal J, Zajac E, Awasthi YC, Awasthi S. Singhal SS, et al. Among authors: zajac e. Biochem Pharmacol. 2005 Aug 1;70(3):481-8. doi: 10.1016/j.bcp.2005.05.005. Biochem Pharmacol. 2005. PMID: 15950949

10

RLIP76 is a major determinant of radiation sensitivity.

Awasthi S, Singhal SS, Yadav S, Singhal J, Drake K, Nadkar A, Zajac E, Wickramarachchi D, Rowe N, Yacoub A, Boor P, Dwivedi S, Dent P, Jarman WE, John B, Awasthi YC. Awasthi S, et al. Among authors: zajac e. Cancer Res. 2005 Jul 15;65(14):6022-8. doi: 10.1158/0008-5472.CAN-05-0968. Cancer Res. 2005. PMID: 16024601

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