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Novel WRN Helicase Inhibitors Selectively Target Microsatellite Unstable Cancer Cells.
Picco G, Rao Y, Al Saedi A, Lee Y, Vieira SF, Bhosle S, May K, Herranz-Ors C, Walker SJ, Shenje R, Dincer C, Gibson F, Banerjee R, Hewitson Z, Werner T, Cottom JE, Peng Y, Deng N, Landis P, Conticelli D, McCarten K, Bush J, Sharma M, Lightfoot H, House D, Milford E, Grant EK, Glogowski MP, Wagner CD, Bantscheff M, Rutkowska-Klute A, Network Uk Group CM, Zappacosta F, Pettinger J, Barthorpe S, Eberl HC, Jones BT, Schneck JL, Murphy DJ, Voest EE, Taygerly JP, DeMartino MP, Coelho MA, Houseley J, Sharma G, Schwartz BJ, Garnett MJ. Picco G, et al. Among authors: eberl hc. Cancer Discov. 2024 Apr 9. doi: 10.1158/2159-8290.CD-24-0052. Online ahead of print. Cancer Discov. 2024. PMID: 38587317
Generation of a pluripotent stem cell line (UMGi270-A) and a corresponding CRISPR/Cas9 modified isogenic control (UMGi270-A-1) from a patient with sudden onset dilated cardiomyopathy harboring a FLNC p.R2187P mutation.
Maurer W, Rebs S, Köhne S, Eberl H, Wollnik B, Zibat A, Streckfuss-Bömeke K. Maurer W, et al. Among authors: eberl h. Stem Cell Res. 2024 Mar 29;77:103409. doi: 10.1016/j.scr.2024.103409. Online ahead of print. Stem Cell Res. 2024. PMID: 38583294 Free article.
Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition.
Burtscher ML, Gade S, Garrido-Rodriguez M, Rutkowska A, Werner T, Eberl HC, Petretich M, Knopf N, Zirngibl K, Grandi P, Bergamini G, Bantscheff M, Fälth-Savitski M, Saez-Rodriguez J. Burtscher ML, et al. Among authors: eberl hc. Mol Syst Biol. 2024 Apr;20(4):458-474. doi: 10.1038/s44320-024-00025-w. Epub 2024 Mar 7. Mol Syst Biol. 2024. PMID: 38454145 Free PMC article.
Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome.
Kutschka I, Bertero E, Wasmus C, Xiao K, Yang L, Chen X, Oshima Y, Fischer M, Erk M, Arslan B, Alhasan L, Grosser D, Ermer KJ, Nickel A, Kohlhaas M, Eberl H, Rebs S, Streckfuss-Bömeke K, Schmitz W, Rehling P, Thum T, Higuchi T, Rabinowitz J, Maack C, Dudek J. Kutschka I, et al. Among authors: eberl h. Basic Res Cardiol. 2023 Nov 6;118(1):47. doi: 10.1007/s00395-023-01017-x. Basic Res Cardiol. 2023. PMID: 37930434 Free PMC article.
80 results