Caldwell GA - Search Results

1

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.

Mazzulli JR, Xu YH, Sun Y, Knight AL, McLean PJ, Caldwell GA, Sidransky E, Grabowski GA, Krainc D. Mazzulli JR, et al. Among authors: caldwell ga. Cell. 2011 Jul 8;146(1):37-52. doi: 10.1016/j.cell.2011.06.001. Epub 2011 Jun 23. Cell. 2011. PMID: 21700325 Free PMC article.

2

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model.

Hamamichi S, Rivas RN, Knight AL, Cao S, Caldwell KA, Caldwell GA. Hamamichi S, et al. Among authors: caldwell ka, caldwell ga. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):728-33. doi: 10.1073/pnas.0711018105. Epub 2008 Jan 8. Proc Natl Acad Sci U S A. 2008. PMID: 18182484 Free PMC article.

3

Generation of stable transgenic C. elegans using microinjection.

Berkowitz LA, Knight AL, Caldwell GA, Caldwell KA. Berkowitz LA, et al. Among authors: caldwell ka, caldwell ga. J Vis Exp. 2008 Aug 15;(18):833. doi: 10.3791/833. J Vis Exp. 2008. PMID: 19066505 Free PMC article.

4

Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes.

Berkowitz LA, Hamamichi S, Knight AL, Harrington AJ, Caldwell GA, Caldwell KA. Berkowitz LA, et al. Among authors: caldwell ka, caldwell ga. J Vis Exp. 2008 Jul 18;(17):835. doi: 10.3791/835. J Vis Exp. 2008. PMID: 19066512 Free PMC article.

5

Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease.

Harrington AJ, Knight AL, Caldwell GA, Caldwell KA. Harrington AJ, et al. Among authors: caldwell ka, caldwell ga. Methods. 2011 Mar;53(3):220-5. doi: 10.1016/j.ymeth.2010.12.036. Epub 2010 Dec 31. Methods. 2011. PMID: 21195766

6

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.

Usenovic M, Knight AL, Ray A, Wong V, Brown KR, Caldwell GA, Caldwell KA, Stagljar I, Krainc D. Usenovic M, et al. Among authors: caldwell ka, caldwell ga. Hum Mol Genet. 2012 Sep 1;21(17):3785-94. doi: 10.1093/hmg/dds206. Epub 2012 May 29. Hum Mol Genet. 2012. PMID: 22645275 Free PMC article.

7

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.

Bornhorst J, Chakraborty S, Meyer S, Lohren H, Brinkhaus SG, Knight AL, Caldwell KA, Caldwell GA, Karst U, Schwerdtle T, Bowman A, Aschner M. Bornhorst J, et al. Among authors: caldwell ka, caldwell ga. Metallomics. 2014 Mar;6(3):476-90. doi: 10.1039/c3mt00325f. Epub 2014 Jan 22. Metallomics. 2014. PMID: 24452053 Free PMC article.

8

The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.

Knight AL, Yan X, Hamamichi S, Ajjuri RR, Mazzulli JR, Zhang MW, Daigle JG, Zhang S, Borom AR, Roberts LR, Lee SK, DeLeon SM, Viollet-Djelassi C, Krainc D, O'Donnell JM, Caldwell KA, Caldwell GA. Knight AL, et al. Among authors: caldwell ka, caldwell ga. Cell Metab. 2014 Jul 1;20(1):145-57. doi: 10.1016/j.cmet.2014.04.017. Epub 2014 May 29. Cell Metab. 2014. PMID: 24882066 Free PMC article.

9

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration.

Mor DE, Tsika E, Mazzulli JR, Gould NS, Kim H, Daniels MJ, Doshi S, Gupta P, Grossman JL, Tan VX, Kalb RG, Caldwell KA, Caldwell GA, Wolfe JH, Ischiropoulos H. Mor DE, et al. Among authors: caldwell ka, caldwell ga. Nat Neurosci. 2017 Nov;20(11):1560-1568. doi: 10.1038/nn.4641. Epub 2017 Sep 18. Nat Neurosci. 2017. PMID: 28920936 Free PMC article.

10

Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.

Yacoubian TA, Slone SR, Harrington AJ, Hamamichi S, Schieltz JM, Caldwell KA, Caldwell GA, Standaert DG. Yacoubian TA, et al. Among authors: caldwell ka, caldwell ga. Cell Death Dis. 2010;1(1):e2. doi: 10.1038/cddis.2009.4. Cell Death Dis. 2010. PMID: 21152247 Free PMC article.

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