A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9.
Chen EI, Li W, Godzik A, Howard EW, Smith JW.
Chen EI, et al. Among authors: godzik a.
J Biol Chem. 2003 May 9;278(19):17158-63. doi: 10.1074/jbc.M210324200. Epub 2003 Feb 18.
J Biol Chem. 2003.
PMID: 12591933
Free article.
I., Kridel, S. J., Howard, E. W., Li, W., Godzik, A., and Smith, J. W. (2002) J. Biol. Chem. 277, 4485-4491). ...Here, we test the hypothesis that this conservative substitution has a role in substrate selectivity. Mutation of Glu(412) in MMP-2 to Asp signifi …
I., Kridel, S. J., Howard, E. W., Li, W., Godzik, A., and Smith, J. W. (2002) J. Biol. Chem. 277, 4485-4491). ...Here, we test …