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Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse.
Tinsley JM, Fairclough RJ, Storer R, Wilkes FJ, Potter AC, Squire SE, Powell DS, Cozzoli A, Capogrosso RF, Lambert A, Wilson FX, Wren SP, De Luca A, Davies KE. Tinsley JM, et al. Among authors: capogrosso rf. PLoS One. 2011 May 6;6(5):e19189. doi: 10.1371/journal.pone.0019189. PLoS One. 2011. PMID: 21573153 Free PMC article.
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies.
Sanarica F, Mantuano P, Conte E, Cozzoli A, Capogrosso RF, Giustino A, Cutrignelli A, Cappellari O, Rolland JF, De Bellis M, Denora N, Camerino GM, De Luca A. Sanarica F, et al. Among authors: capogrosso rf. Pharmacol Res. 2019 Jul;145:104260. doi: 10.1016/j.phrs.2019.104260. Epub 2019 May 3. Pharmacol Res. 2019. PMID: 31059789
Multiple pathological events in exercised dystrophic mdx mice are targeted by pentoxifylline: outcome of a large array of in vivo and ex vivo tests.
Burdi R, Rolland JF, Fraysse B, Litvinova K, Cozzoli A, Giannuzzi V, Liantonio A, Camerino GM, Sblendorio V, Capogrosso RF, Palmieri B, Andreetta F, Confalonieri P, De Benedictis L, Montagnani M, De Luca A. Burdi R, et al. Among authors: capogrosso rf. J Appl Physiol (1985). 2009 Apr;106(4):1311-24. doi: 10.1152/japplphysiol.90985.2008. Epub 2009 Jan 8. J Appl Physiol (1985). 2009. PMID: 19131478 Free article.
Contractile efficiency of dystrophic mdx mouse muscle: in vivo and ex vivo assessment of adaptation to exercise of functional end points.
Capogrosso RF, Mantuano P, Cozzoli A, Sanarica F, Massari AM, Conte E, Fonzino A, Giustino A, Rolland JF, Quaranta A, De Bellis M, Camerino GM, Grange RW, De Luca A. Capogrosso RF, et al. J Appl Physiol (1985). 2017 Apr 1;122(4):828-843. doi: 10.1152/japplphysiol.00776.2015. Epub 2017 Jan 5. J Appl Physiol (1985). 2017. PMID: 28057817 Free article.
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy.
Mantuano P, Sanarica F, Conte E, Morgese MG, Capogrosso RF, Cozzoli A, Fonzino A, Quaranta A, Rolland JF, De Bellis M, Camerino GM, Trabace L, De Luca A. Mantuano P, et al. Among authors: capogrosso rf. Biochem Pharmacol. 2018 Aug;154:89-103. doi: 10.1016/j.bcp.2018.04.022. Epub 2018 Apr 21. Biochem Pharmacol. 2018. PMID: 29684379
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