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Acute 2-phenyl-3-(phenylselanyl)benzofuran treatment reverses the neurobehavioral alterations induced by sleep deprivation in mice.
da Silva Gonçalves L, Rusch G, Alves AG, Krüger LD, Paim MP, Cristóvão Martins C, Pereira da Motta K, Sebastião Dos Santos Neto J, Luchese C, Antunes Wilhelm E, Augusto Brüning C, Folharini Bortolatto C. da Silva Gonçalves L, et al. Biochem Pharmacol. 2024 Jun 5:116339. doi: 10.1016/j.bcp.2024.116339. Online ahead of print. Biochem Pharmacol. 2024. PMID: 38848781
Brain structures were utilized to evaluate oxidative stress markers, monoamine oxidase (MAO) and acetylcholinesterase (AChE) activities. ...
Brain structures were utilized to evaluate oxidative stress markers, monoamine oxidase (MAO) and acetylcholinesterase (AChE) a …
Discovery of novel benzimidazole derivatives as selective and reversible monoamine oxidase B inhibitors for Parkinson's disease treatment.
Lv Y, Fan M, He J, Song X, Guo J, Gao B, Zhang J, Zhang C, Xie Y. Lv Y, et al. Eur J Med Chem. 2024 Jun 2;274:116566. doi: 10.1016/j.ejmech.2024.116566. Online ahead of print. Eur J Med Chem. 2024. PMID: 38838545
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The development of novel scaffolds for human monoamine oxidase B (hMAO-B) inhibitors with reversible properties r …
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pa …
Structure and Ligand Based Virtual Screening and MPO Topological Analysis of Triazolo Thiadiazepine-fused Coumarin Derivatives as Anti-Parkinson Drug Candidates.
Pereira AMG, de Oliveira VM, da Rocha MN, Roberto CHA, Cajazeiras FFM, Guedes JM, Marinho MM, Teixeira AMR, Marinho ES, de Lima-Neto P, Dos Santos HS. Pereira AMG, et al. Mol Biotechnol. 2024 Jun 4. doi: 10.1007/s12033-024-01200-y. Online ahead of print. Mol Biotechnol. 2024. PMID: 38834896
Parkinson's disease (PD) is a debilitating condition that can cause locomotor problems in affected patients, such as tremors and body rigidity. PD therapy often includes the use of monoamine oxidase B (MAOB) inhibitors, particularly phenylhalogen compounds and couma …
Parkinson's disease (PD) is a debilitating condition that can cause locomotor problems in affected patients, such as tremors and body rigidi …
Tyrosinase deficiency impairs social novelty preference in mice.
Aizawa S, Yamamuro Y. Aizawa S, et al. Neuroreport. 2024 May 30. doi: 10.1097/WNR.0000000000002055. Online ahead of print. Neuroreport. 2024. PMID: 38829918
We also found that the hippocampal expression of genes involved in catecholamine metabolism, such as monoamine oxidase A and catechol-O-methyltransferase, were significantly decreased in tyrosinase-deficient B10-c mice. ...
We also found that the hippocampal expression of genes involved in catecholamine metabolism, such as monoamine oxidase A and c …
Targeting Biometals in Alzheimer's Disease with Metal Chelating Agents Including Coumarin Derivatives.
Gucký A, Hamuľaková S. Gucký A, et al. CNS Drugs. 2024 Jun 3. doi: 10.1007/s40263-024-01093-0. Online ahead of print. CNS Drugs. 2024. PMID: 38829443 Review.
Various coumarin derivatives match this description and apart from being able to chelate metal ions, they exhibit the capacity to inhibit cholinesterases (ChEs) and monoamine oxidase B (MAO-B) while also possessing antioxidant, anti-inflammatory, and numerous other …
Various coumarin derivatives match this description and apart from being able to chelate metal ions, they exhibit the capacity to inhibit ch …
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