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The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain.
Fredriksson R, Sreedharan S, Nordenankar K, Alsiö J, Lindberg FA, Hutchinson A, Eriksson A, Roshanbin S, Ciuculete DM, Klockars A, Todkar A, Hägglund MG, Hellsten SV, Hindlycke V, Västermark Å, Shevchenko G, Olivo G, K C, Kullander K, Moazzami A, Bergquist J, Olszewski PK, Schiöth HB. Fredriksson R, et al. Among authors: sreedharan s. PLoS Genet. 2019 Dec 4;15(12):e1008455. doi: 10.1371/journal.pgen.1008455. eCollection 2019 Dec. PLoS Genet. 2019. PMID: 31800589 Free PMC article.
The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children.
Almén MS, Jacobsson JA, Shaik JH, Olszewski PK, Cedernaes J, Alsiö J, Sreedharan S, Levine AS, Fredriksson R, Marcus C, Schiöth HB. Almén MS, et al. Among authors: sreedharan s. BMC Med Genet. 2010 Apr 9;11:58. doi: 10.1186/1471-2350-11-58. BMC Med Genet. 2010. PMID: 20380707 Free PMC article.
The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus.
Sreedharan S, Almén MS, Carlini VP, Haitina T, Stephansson O, Sommer WH, Heilig M, de Barioglio SR, Fredriksson R, Schiöth HB. Sreedharan S, et al. FEBS J. 2011 Dec;278(24):4881-94. doi: 10.1111/j.1742-4658.2011.08388.x. Epub 2011 Oct 31. FEBS J. 2011. PMID: 21981325 Free article.
mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts.
Caruso V, Sreedharan S, Carlini VP, Jacobsson JA, Haitina T, Hammer J, Stephansson O, Crona F, Sommer WH, Risérus U, Lannfelt L, Marcus C, Heilig M, de Barioglio SR, Fredriksson R, Schiöth HB. Caruso V, et al. Among authors: sreedharan s. Gene. 2016 May 1;581(2):139-45. doi: 10.1016/j.gene.2016.01.044. Epub 2016 Jan 29. Gene. 2016. PMID: 26827797
Multimodal Eph/Ephrin signaling controls several phases of urogenital development.
Peuckert C, Aresh B, Holenya P, Adams D, Sreedharan S, Porthin A, Andersson L, Pettersson H, Wölfl S, Klein R, Oxburgh L, Kullander K. Peuckert C, et al. Among authors: sreedharan s. Kidney Int. 2016 Aug;90(2):373-388. doi: 10.1016/j.kint.2016.04.021. Epub 2016 Jun 22. Kidney Int. 2016. PMID: 27344203 Free article.
314 results