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3,115 results

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Page 1
Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists.
Guay D, Beaulieu C, Belley M, Crane SN, DeLuca J, Gareau Y, Hamel M, Henault M, Hyjazie H, Kargman S, Chan CC, Xu L, Gordon R, Li L, Mamane Y, Morin N, Mancini J, Thérien M, Tranmer G, Truong VL, Wang Z, Black WC. Guay D, et al. Among authors: gordon r. Bioorg Med Chem Lett. 2011 May 15;21(10):2832-5. doi: 10.1016/j.bmcl.2011.03.084. Epub 2011 Mar 30. Bioorg Med Chem Lett. 2011. PMID: 21507642
Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists.
Belley M, Gallant M, Roy B, Houde K, Lachance N, Labelle M, Trimble LA, Chauret N, Li C, Sawyer N, Tremblay N, Lamontagne S, Carrière MC, Denis D, Greig GM, Slipetz D, Metters KM, Gordon R, Chan CC, Zamboni RJ. Belley M, et al. Among authors: gordon r. Bioorg Med Chem Lett. 2005 Feb 1;15(3):527-30. doi: 10.1016/j.bmcl.2004.11.051. Bioorg Med Chem Lett. 2005. PMID: 15664806
Comparison between two classes of selective EP(3) antagonists and their biological activities.
Belley M, Chan CC, Gareau Y, Gallant M, Juteau H, Houde K, Lachance N, Labelle M, Sawyer N, Tremblay N, Lamontagne S, Carrière MC, Denis D, Greig GM, Slipetz D, Gordon R, Chauret N, Li C, Zamboni RJ, Metters KM. Belley M, et al. Among authors: gordon r. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. doi: 10.1016/j.bmcl.2006.08.025. Epub 2006 Aug 22. Bioorg Med Chem Lett. 2006. PMID: 16931013
., Carriere, M.-C., Denis, D., Greig, G. M., Slipetz, D., Metters, K. M., Gordon, R., Chan, C. C., Zamboni, R. J. Bioorg. Med. Chem. Lett.2005, 15, 527] and the acylsulfonamides of ortho-(arylmethyl)cinnamates. ...
., Carriere, M.-C., Denis, D., Greig, G. M., Slipetz, D., Metters, K. M., Gordon, R., Chan, C. C., Zamboni, R. J. Bioor …
Nicotinic acids: liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy.
Powell DA, Black WC, Bleasby K, Chan CC, Deschenes D, Gagnon M, Gordon R, Guay J, Guiral S, Hafey MJ, Huang Z, Isabel E, Leblanc Y, Styhler A, Xu LJ, Zhang L, Oballa RM. Powell DA, et al. Among authors: gordon r. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7281-6. doi: 10.1016/j.bmcl.2011.10.040. Epub 2011 Oct 18. Bioorg Med Chem Lett. 2011. PMID: 22047692
Pyridazinones as selective cyclooxygenase-2 inhibitors.
Li CS, Brideau C, Chan CC, Savoie C, Claveau D, Charleson S, Gordon R, Greig G, Gauthier JY, Lau CK, Riendeau D, Thérien M, Wong E, Prasit P. Li CS, et al. Among authors: gordon r. Bioorg Med Chem Lett. 2003 Feb 24;13(4):597-600. doi: 10.1016/s0960-894x(02)01045-4. Bioorg Med Chem Lett. 2003. PMID: 12639538
The development of potent non-peptidic PTP-1B inhibitors.
Dufresne C, Roy P, Wang Z, Asante-Appiah E, Cromlish W, Boie Y, Forghani F, Desmarais S, Wang Q, Skorey K, Waddleton D, Ramachandran C, Kennedy BP, Xu L, Gordon R, Chan CC, Leblanc Y. Dufresne C, et al. Among authors: gordon r. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1039-42. doi: 10.1016/j.bmcl.2003.11.048. Bioorg Med Chem Lett. 2004. PMID: 15013019
Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors.
Isabel E, Powell DA, Black WC, Chan CC, Crane S, Gordon R, Guay J, Guiral S, Huang Z, Robichaud J, Skorey K, Tawa P, Xu L, Zhang L, Oballa R. Isabel E, et al. Among authors: gordon r. Bioorg Med Chem Lett. 2011 Jan 1;21(1):479-83. doi: 10.1016/j.bmcl.2010.10.107. Epub 2010 Oct 26. Bioorg Med Chem Lett. 2011. PMID: 21074991
Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.
Oballa RM, Belair L, Black WC, Bleasby K, Chan CC, Desroches C, Du X, Gordon R, Guay J, Guiral S, Hafey MJ, Hamelin E, Huang Z, Kennedy B, Lachance N, Landry F, Li CS, Mancini J, Normandin D, Pocai A, Powell DA, Ramtohul YK, Skorey K, Sørensen D, Sturkenboom W, Styhler A, Waddleton DM, Wang H, Wong S, Xu L, Zhang L. Oballa RM, et al. Among authors: gordon r. J Med Chem. 2011 Jul 28;54(14):5082-96. doi: 10.1021/jm200319u. Epub 2011 Jun 28. J Med Chem. 2011. PMID: 21661758
3,115 results