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Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Zheng X, Hudyma TW, Martin SW, Bergstrom C, Ding M, He F, Romine J, Poss MA, Kadow JF, Chang CH, Wan J, Witmer MR, Morin P, Camac DM, Sheriff S, Beno BR, Rigat KL, Wang YK, Fridell R, Lemm J, Qiu D, Liu M, Voss S, Pelosi L, Roberts SB, Gao M, Knipe J, Gentles RG. Zheng X, et al. Among authors: kadow jf. Bioorg Med Chem Lett. 2011 May 15;21(10):2925-9. doi: 10.1016/j.bmcl.2011.03.067. Epub 2011 Mar 23. Bioorg Med Chem Lett. 2011. PMID: 21486696
Synthesis of metabolically blocked paclitaxel analogues.
Wittman MD, Altstadt TJ, Fairchild C, Hansel S, Johnston K, Kadow JF, Long BH, Rose WC, Vyas DM, Wu MJ, Zoeckler ME. Wittman MD, et al. Among authors: kadow jf. Bioorg Med Chem Lett. 2001 Mar 26;11(6):809-10. doi: 10.1016/s0960-894x(01)00066-x. Bioorg Med Chem Lett. 2001. PMID: 11277525
Synthesis of a novel C-10 spiro-epoxide of paclitaxel.
Walker MA, Johnson TD, Huang S, Vyas DM, Kadow JF. Walker MA, et al. Among authors: kadow jf. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1683-5. doi: 10.1016/s0960-894x(01)00280-3. Bioorg Med Chem Lett. 2001. PMID: 11425537
The discovery of BMS-275183: an orally efficacious novel taxane.
Mastalerz H, Cook D, Fairchild CR, Hansel S, Johnson W, Kadow JF, Long BH, Rose WC, Tarrant J, Wu MJ, Xue MQ, Zhang G, Zoeckler M, Vyas DM. Mastalerz H, et al. Among authors: kadow jf. Bioorg Med Chem. 2003 Oct 1;11(20):4315-23. doi: 10.1016/s0968-0896(03)00495-4. Bioorg Med Chem. 2003. PMID: 13129567
Synthesis and biological activity of macrocyclic taxane analogues.
Tarrant JG, Cook D, Fairchild C, Kadow JF, Long BH, Rose WC, Vyas D. Tarrant JG, et al. Among authors: kadow jf. Bioorg Med Chem Lett. 2004 May 17;14(10):2555-8. doi: 10.1016/j.bmcl.2004.02.086. Bioorg Med Chem Lett. 2004. PMID: 15109650
New dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Fink BE, Vite GD, Mastalerz H, Kadow JF, Kim SH, Leavitt KJ, Du K, Crews D, Mitt T, Wong TW, Hunt JT, Vyas DM, Tokarski JS. Fink BE, et al. Among authors: kadow jf. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4774-9. doi: 10.1016/j.bmcl.2005.07.027. Bioorg Med Chem Lett. 2005. PMID: 16111887
Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives.
Wang T, Kadow JF, Zhang Z, Yin Z, Gao Q, Wu D, Parker DD, Yang Z, Zadjura L, Robinson BA, Gong YF, Spicer TP, Blair WS, Shi PY, Yamanaka G, Lin PF, Meanwell NA. Wang T, et al. Among authors: kadow jf. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5140-5. doi: 10.1016/j.bmcl.2009.07.076. Epub 2009 Jul 18. Bioorg Med Chem Lett. 2009. PMID: 19664921
78 results