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Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.
Fletcher S, Singh J, Zhang X, Yue P, Page BD, Sharmeen S, Shahani VM, Zhao W, Schimmer AD, Turkson J, Gunning PT. Fletcher S, et al. Among authors: schimmer ad. Chembiochem. 2009 Aug 17;10(12):1959-64. doi: 10.1002/cbic.200900172. Chembiochem. 2009. PMID: 19644994 Free PMC article. No abstract available.
The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma.
Spagnuolo PA, Hu J, Hurren R, Wang X, Gronda M, Sukhai MA, Di Meo A, Boss J, Ashali I, Beheshti Zavareh R, Fine N, Simpson CD, Sharmeen S, Rottapel R, Schimmer AD. Spagnuolo PA, et al. Among authors: schimmer ad. Blood. 2010 Jun 10;115(23):4824-33. doi: 10.1182/blood-2009-09-243055. Epub 2010 Mar 26. Blood. 2010. PMID: 20348394 Free article.
The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells.
Sharmeen S, Skrtic M, Sukhai MA, Hurren R, Gronda M, Wang X, Fonseca SB, Sun H, Wood TE, Ward R, Minden MD, Batey RA, Datti A, Wrana J, Kelley SO, Schimmer AD. Sharmeen S, et al. Among authors: schimmer ad. Blood. 2010 Nov 4;116(18):3593-603. doi: 10.1182/blood-2010-01-262675. Epub 2010 Jul 19. Blood. 2010. PMID: 20644115 Free article.
New sources of drugs for hematologic malignancies.
Sukhai MA, Spagnuolo PA, Weir S, Kasper J, Patton L, Schimmer AD. Sukhai MA, et al. Among authors: schimmer ad. Blood. 2011 Jun 23;117(25):6747-55. doi: 10.1182/blood-2011-02-315283. Epub 2011 Apr 21. Blood. 2011. PMID: 21511957 Free PMC article. Review.
295 results