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Enhanced apoptosis and tumor regression induced by a direct agonist antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2.
Motoki K, Mori E, Matsumoto A, Thomas M, Tomura T, Humphreys R, Albert V, Muto M, Yoshida H, Aoki M, Tamada T, Kuroki R, Yoshida H, Ishida I, Ware CF, Kataoka S. Motoki K, et al. Among authors: humphreys r. Clin Cancer Res. 2005 Apr 15;11(8):3126-35. doi: 10.1158/1078-0432.CCR-04-1867. Clin Cancer Res. 2005. PMID: 15837769
A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR.
Ren B, Song K, Parangi S, Jin T, Ye M, Humphreys R, Duquette M, Zhang X, Benhaga N, Lawler J, Khosravi-Far R. Ren B, et al. Among authors: humphreys r. Cancer Res. 2009 May 1;69(9):3856-65. doi: 10.1158/0008-5472.CAN-08-2940. Epub 2009 Apr 14. Cancer Res. 2009. PMID: 19366809 Free PMC article.
Phase II trial of mapatumumab, a fully human agonist monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), in combination with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer.
von Pawel J, Harvey JH, Spigel DR, Dediu M, Reck M, Cebotaru CL, Humphreys RC, Gribbin MJ, Fox NL, Camidge DR. von Pawel J, et al. Among authors: humphreys rc. Clin Lung Cancer. 2014 May;15(3):188-196.e2. doi: 10.1016/j.cllc.2013.12.005. Epub 2013 Dec 27. Clin Lung Cancer. 2014. PMID: 24560012 Clinical Trial.
Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo.
Marini P, Denzinger S, Schiller D, Kauder S, Welz S, Humphreys R, Daniel PT, Jendrossek V, Budach W, Belka C. Marini P, et al. Among authors: humphreys r. Oncogene. 2006 Aug 24;25(37):5145-54. doi: 10.1038/sj.onc.1209516. Epub 2006 Apr 24. Oncogene. 2006. PMID: 16636678
411 results