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1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines: a series of potent and selective dopamine D(3) receptor antagonists.
Micheli F, Bonanomi G, Blaney FE, Braggio S, Capelli AM, Checchia A, Curcuruto O, Damiani F, Fabio RD, Donati D, Gentile G, Gribble A, Hamprecht D, Tedesco G, Terreni S, Tarsi L, Lightfoot A, Stemp G, Macdonald G, Smith A, Pecoraro M, Petrone M, Perini O, Piner J, Rossi T, Worby A, Pilla M, Valerio E, Griffante C, Mugnaini M, Wood M, Scott C, Andreoli M, Lacroix L, Schwarz A, Gozzi A, Bifone A, Ashby CR Jr, Hagan JJ, Heidbreder C. Micheli F, et al. J Med Chem. 2007 Oct 18;50(21):5076-89. doi: 10.1021/jm0705612. Epub 2007 Sep 15. J Med Chem. 2007. PMID: 17867665
New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part 2: [g]-fused and hetero-fused systems.
Micheli F, Bonanomi G, Braggio S, Capelli AM, Damiani F, Di Fabio R, Donati D, Gentile G, Hamprecht D, Perini O, Petrone M, Tedesco G, Terreni S, Worby A, Heidbreder C. Micheli F, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):908-12. doi: 10.1016/j.bmcl.2007.12.042. Epub 2008 Jan 4. Bioorg Med Chem Lett. 2008. PMID: 18178090
New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems.
Micheli F, Bonanomi G, Braggio S, Capelli AM, Celestini P, Damiani F, Di Fabio R, Donati D, Gagliardi S, Gentile G, Hamprecht D, Petrone M, Radaelli S, Tedesco G, Terreni S, Worby A, Heidbreder C. Micheli F, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):901-7. doi: 10.1016/j.bmcl.2007.12.066. Epub 2008 Jan 3. Bioorg Med Chem Lett. 2008. PMID: 18248991
1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: a new series of potent and selective dopamine D(3) receptor antagonists.
Micheli F, Arista L, Bonanomi G, Blaney FE, Braggio S, Capelli AM, Checchia A, Damiani F, Di-Fabio R, Fontana S, Gentile G, Griffante C, Hamprecht D, Marchioro C, Mugnaini M, Piner J, Ratti E, Tedesco G, Tarsi L, Terreni S, Worby A, Ashby CR Jr, Heidbreder C. Micheli F, et al. J Med Chem. 2010 Jan 14;53(1):374-91. doi: 10.1021/jm901319p. J Med Chem. 2010. PMID: 19891474
The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure.
Holmes IP, Blunt RJ, Lorthioir OE, Blowers SM, Gribble A, Payne AH, Stansfield IG, Wood M, Woollard PM, Reavill C, Howes CM, Micheli F, Di Fabio R, Donati D, Terreni S, Hamprecht D, Arista L, Worby A, Watson SP. Holmes IP, et al. Among authors: micheli f. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2013-6. doi: 10.1016/j.bmcl.2010.01.090. Epub 2010 Jan 25. Bioorg Med Chem Lett. 2010. PMID: 20153647
663 results