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Iminosugars past, present and future: medicines for tomorrow.
Horne G, Wilson FX, Tinsley J, Williams DH, Storer R. Horne G, et al. Among authors: tinsley j. Drug Discov Today. 2011 Feb;16(3-4):107-18. doi: 10.1016/j.drudis.2010.08.017. Epub 2010 Sep 21. Drug Discov Today. 2011. PMID: 20817006 Review.
Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.
Wilkinson IVL, Perkins KJ, Dugdale H, Moir L, Vuorinen A, Chatzopoulou M, Squire SE, Monecke S, Lomow A, Geese M, Charles PD, Burch P, Tinsley JM, Wynne GM, Davies SG, Wilson FX, Rastinejad F, Mohammed S, Davies KE, Russell AJ. Wilkinson IVL, et al. Among authors: tinsley jm. Angew Chem Int Ed Engl. 2020 Feb 3;59(6):2420-2428. doi: 10.1002/anie.201912392. Epub 2020 Jan 3. Angew Chem Int Ed Engl. 2020. PMID: 31755636 Free PMC article.
Second-generation compound for the modulation of utrophin in the therapy of DMD.
Guiraud S, Squire SE, Edwards B, Chen H, Burns DT, Shah N, Babbs A, Davies SG, Wynne GM, Russell AJ, Elsey D, Wilson FX, Tinsley JM, Davies KE. Guiraud S, et al. Among authors: tinsley jm. Hum Mol Genet. 2015 Aug 1;24(15):4212-24. doi: 10.1093/hmg/ddv154. Epub 2015 May 1. Hum Mol Genet. 2015. PMID: 25935002 Free PMC article.
Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies.
Mellone M, Kestoras D, Andrews MR, Dassie E, Crowther RA, Stokin GB, Tinsley J, Horne G, Goedert M, Tolkovsky AM, Spillantini MG. Mellone M, et al. Among authors: tinsley j. J Neurosci. 2013 Nov 13;33(46):18175-89. doi: 10.1523/JNEUROSCI.4933-12.2013. J Neurosci. 2013. PMID: 24227726 Free PMC article.
Utrophin: a potential replacement for dystrophin?
Tinsley JM, Davies KE. Tinsley JM, et al. Neuromuscul Disord. 1993 Sep-Nov;3(5-6):537-9. doi: 10.1016/0960-8966(93)90111-v. Neuromuscul Disord. 1993. PMID: 8186707 Review.
Molecular and functional analysis of the utrophin promoter.
Dennis CL, Tinsley JM, Deconinck AE, Davies KE. Dennis CL, et al. Among authors: tinsley jm. Nucleic Acids Res. 1996 May 1;24(9):1646-52. doi: 10.1093/nar/24.9.1646. Nucleic Acids Res. 1996. PMID: 8649981 Free PMC article.
Non-toxic ubiquitous over-expression of utrophin in the mdx mouse.
Fisher R, Tinsley JM, Phelps SR, Squire SE, Townsend ER, Martin JE, Davies KE. Fisher R, et al. Among authors: tinsley jm. Neuromuscul Disord. 2001 Nov;11(8):713-21. doi: 10.1016/s0960-8966(01)00220-6. Neuromuscul Disord. 2001. PMID: 11595513
221 results