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Page 1
Identification and hit-to-lead optimization of a novel class of CB1 antagonists.
Letourneau JJ, Jokiel P, Olson J, Riviello CM, Ho KK, McAleer L, Yang J, Swanson RN, Baker J, Cowley P, Edwards D, Ward N, Ohlmeyer MH, Webb ML. Letourneau JJ, et al. Among authors: swanson rn. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5449-53. doi: 10.1016/j.bmcl.2010.07.091. Epub 2010 Jul 25. Bioorg Med Chem Lett. 2010. PMID: 20719511
Structure-activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists.
Palin R, Abernethy L, Ansari N, Cameron K, Clarkson T, Dempster M, Dunn D, Easson AM, Edwards D, Maclean J, Everett K, Feilden H, Ho KK, Kultgen S, Littlewood P, McArthur D, McGregor D, McLuskey H, Neagu I, Neale S, Nisbet LA, Ohlmeyer M, Pham Q, Ratcliffe P, Rong Y, Roughton A, Sammons M, Swanson R, Tracey H, Walker G. Palin R, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):892-8. doi: 10.1016/j.bmcl.2010.12.092. Epub 2010 Dec 23. Bioorg Med Chem Lett. 2011. PMID: 21236666
Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles.
Ratcliffe P, Abernethy L, Ansari N, Cameron K, Clarkson T, Dempster M, Dunn D, Easson AM, Edwards D, Everett K, Feilden H, Ho KK, Kultgen S, Littlewood P, Maclean J, McArthur D, McGregor D, McLuskey H, Neagu I, Nimz O, Nisbet LA, Ohlmeyer M, Palin R, Pham Q, Rong Y, Roughton A, Sammons M, Swanson R, Tracey H, Walker G. Ratcliffe P, et al. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4652-7. doi: 10.1016/j.bmcl.2011.01.051. Epub 2011 Jan 26. Bioorg Med Chem Lett. 2011. PMID: 21723725
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.
Chiba J, Takayama G, Takashi T, Yokoyama M, Nakayama A, Baldwin JJ, McDonald E, Moriarty KJ, Sarko CR, Saionz KW, Swanson R, Hussain Z, Wong A, Machinaga N. Chiba J, et al. Bioorg Med Chem. 2006 Apr 15;14(8):2725-46. doi: 10.1016/j.bmc.2005.11.058. Epub 2005 Dec 27. Bioorg Med Chem. 2006. PMID: 16377201
Combinatorial gene expression using multiple episomal vectors.
Horlick RA, Schilling AE, Samama P, Swanson RN, Fitzpatrick VD, Robbins AK, Damaj B. Horlick RA, et al. Among authors: swanson rn. Gene. 2000 Feb 8;243(1-2):187-94. doi: 10.1016/s0378-1119(99)00561-2. Gene. 2000. PMID: 10675627
Safety of long-term use of linezolid: results of an open-label study.
Vazquez JA, Arnold AC, Swanson RN, Biswas P, Bassetti M. Vazquez JA, et al. Among authors: swanson rn. Ther Clin Risk Manag. 2016 Sep 1;12:1347-54. doi: 10.2147/TCRM.S109444. eCollection 2016. Ther Clin Risk Manag. 2016. PMID: 27621644 Free PMC article.
Novel antifungal drug discovery based on targeting pathways regulating the fungus-conserved Upc2 transcription factor.
Gallo-Ebert C, Donigan M, Stroke IL, Swanson RN, Manners MT, Francisco J, Toner G, Gallagher D, Huang CY, Gygax SE, Webb M, Nickels JT Jr. Gallo-Ebert C, et al. Among authors: swanson rn. Antimicrob Agents Chemother. 2014;58(1):258-66. doi: 10.1128/AAC.01677-13. Epub 2013 Oct 21. Antimicrob Agents Chemother. 2014. PMID: 24145546 Free PMC article.
49 results