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Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF.
Paula-Lima AC, Adasme T, SanMartín C, Sebollela A, Hetz C, Carrasco MA, Ferreira ST, Hidalgo C. Paula-Lima AC, et al. Among authors: hetz c. Antioxid Redox Signal. 2011 Apr 1;14(7):1209-23. doi: 10.1089/ars.2010.3287. Epub 2011 Jan 6. Antioxid Redox Signal. 2011. PMID: 20712397
DEF8 and Autophagy-Associated Genes Are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients, and a Transgenic Model of the Disease.
Leyton E, Matus D, Espinoza S, Benitez JM, Cortés BI, Gomez W, Arévalo NB, Murgas P, Manque P, Woehlbier U, Duran-Aniotz C, Hetz C, Behrens MI, SanMartín CD, Nassif M. Leyton E, et al. Among authors: hetz c. J Alzheimers Dis. 2021;82(s1):S163-S178. doi: 10.3233/JAD-201264. J Alzheimers Dis. 2021. PMID: 33612542
Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer's Disease.
Espinoza S, Grunenwald F, Gomez W, García F, Abarzúa-Catalan L, Oyarce-Pezoa S, Hernandez MF, Cortés BI, Uhrig M, Ponce DP, Durán-Aniotz C, Hetz C, SanMartín CD, Cornejo VH, Ezquer F, Parra V, Behrens MI, Manque PA, Rojas-Rivera D, Vidal RL, Woehlbier U, Nassif M. Espinoza S, et al. Among authors: hetz c. Cells. 2022 Jun 7;11(12):1860. doi: 10.3390/cells11121860. Cells. 2022. PMID: 35740989 Free PMC article.
The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis.
Duran-Aniotz C, Poblete N, Rivera-Krstulovic C, Ardiles ÁO, Díaz-Hung ML, Tamburini G, Sabusap CMP, Gerakis Y, Cabral-Miranda F, Diaz J, Fuentealba M, Arriagada D, Muñoz E, Espinoza S, Martinez G, Quiroz G, Sardi P, Medinas DB, Contreras D, Piña R, Lourenco MV, Ribeiro FC, Ferreira ST, Rozas C, Morales B, Plate L, Gonzalez-Billault C, Palacios AG, Hetz C. Duran-Aniotz C, et al. Among authors: hetz c. Mol Ther. 2023 Jul 5;31(7):2240-2256. doi: 10.1016/j.ymthe.2023.03.028. Epub 2023 Apr 4. Mol Ther. 2023. PMID: 37016577
Regulation of Memory Formation by the Transcription Factor XBP1.
Martínez G, Vidal RL, Mardones P, Serrano FG, Ardiles AO, Wirth C, Valdés P, Thielen P, Schneider BL, Kerr B, Valdés JL, Palacios AG, Inestrosa NC, Glimcher LH, Hetz C. Martínez G, et al. Among authors: hetz c. Cell Rep. 2016 Feb 16;14(6):1382-1394. doi: 10.1016/j.celrep.2016.01.028. Epub 2016 Feb 4. Cell Rep. 2016. PMID: 26854229 Free article.
256 results