Xia CQ - Search Results

1

Inhibition of hepatic organic anion-transporting polypeptide by RNA interference in sandwich-cultured human hepatocytes: an in vitro model to assess transporter-mediated drug-drug interactions.

Liao M, Raczynski AR, Chen M, Chuang BC, Zhu Q, Shipman R, Morrison J, Lee D, Lee FW, Balani SK, Xia CQ. Liao M, et al. Among authors: xia cq. Drug Metab Dispos. 2010 Sep;38(9):1612-22. doi: 10.1124/dmd.110.032995. Epub 2010 Jun 1. Drug Metab Dispos. 2010. PMID: 20516252

2

Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes.

Lu C, Li P, Gallegos R, Uttamsingh V, Xia CQ, Miwa GT, Balani SK, Gan LS. Lu C, et al. Among authors: xia cq. Drug Metab Dispos. 2006 Sep;34(9):1600-5. doi: 10.1124/dmd.106.010793. Epub 2006 Jun 21. Drug Metab Dispos. 2006. PMID: 16790553

3

Culture duration-, donor-, and medium-dependent changes in OATP1B3-mediated telmisartan uptake in human hepatocytes.

Zhu Q, Xia H, Xia CQ, Yang Q, Doshi U, Li AP, Liao M. Zhu Q, et al. Among authors: xia h, xia cq. Drug Metab Lett. 2014 Jul;7(2):117-25. doi: 10.2174/1872312808666140317153311. Drug Metab Lett. 2014. PMID: 24628404

4

Biotransformation Pathways and Metabolite Profiles of Oral [¹⁴C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.

Pusalkar S, Zhou X, Li Y, Cohen L, Yang JJ, Balani SK, Xia C, Shyu WC, Lu C, Venkatakrishnan K, Chowdhury SK. Pusalkar S, et al. Drug Metab Dispos. 2020 Mar;48(3):217-229. doi: 10.1124/dmd.119.087338. Epub 2020 Jan 7. Drug Metab Dispos. 2020. PMID: 31911485 Free PMC article.

5

P-glycoprotein and breast cancer resistance protein affect disposition of tandutinib, a tyrosine kinase inhibitor.

Yang JJ, Milton MN, Yu S, Liao M, Liu N, Wu JT, Gan L, Balani SK, Lee FW, Prakash S, Xia CQ. Yang JJ, et al. Among authors: xia cq. Drug Metab Lett. 2010 Dec;4(4):201-12. doi: 10.2174/187231210792928279. Drug Metab Lett. 2010. PMID: 20670210

6

Emerging in vitro tools to evaluate cytochrome P450 and transporter-mediated drug-drug interactions.

Lu C, Liao M, Cohen L, Xia CQ. Lu C, et al. Among authors: xia cq. Curr Drug Discov Technol. 2010 Sep;7(3):199-222. doi: 10.2174/157016310793180549. Curr Drug Discov Technol. 2010. PMID: 20843292 Review.

7

Utilizing In Vitro Dissolution-Permeation Chamber for the Quantitative Prediction of pH-Dependent Drug-Drug Interactions with Acid-Reducing Agents: a Comparison with Physiologically Based Pharmacokinetic Modeling.

Zhu AZ, Ho MD, Gemski CK, Chuang BC, Liao M, Xia CQ. Zhu AZ, et al. Among authors: xia cq. AAPS J. 2016 Nov;18(6):1512-1523. doi: 10.1208/s12248-016-9972-4. Epub 2016 Sep 6. AAPS J. 2016. PMID: 27600136

8

Preclinical absorption, distribution, metabolism, excretion and pharmacokinetics of a novel selective inhibitor of breast cancer resistance protein (BCRP).

Liao M, Chuang BC, Zhu Q, Li Y, Guan E, Yu S, Yang J, Prakash S, Xia CQ. Liao M, et al. Among authors: xia cq. Xenobiotica. 2018 May;48(5):467-477. doi: 10.1080/00498254.2017.1328147. Epub 2017 May 31. Xenobiotica. 2018. PMID: 28485193

9

Efflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug-drug interaction profiles.

Shi P, Liao M, Chuang BC, Griffin R, Shi J, Hyer M, Fallon JK, Smith PC, Li C, Xia CQ. Shi P, et al. Among authors: xia cq. Xenobiotica. 2018 Nov;48(11):1173-1183. doi: 10.1080/00498254.2017.1397812. Epub 2017 Nov 16. Xenobiotica. 2018. PMID: 29098941

10

CYP Suppression in Human Hepatocytes by Monomethyl Auristatin E, the Payload in Brentuximab Vedotin (Adcetris^®), is Associated with Microtubule Disruption.

Wolenski FS, Xia CQ, Ma B, Han TH, Shyu WC, Balani SK. Wolenski FS, et al. Among authors: xia cq. Eur J Drug Metab Pharmacokinet. 2018 Jun;43(3):347-354. doi: 10.1007/s13318-017-0455-5. Eur J Drug Metab Pharmacokinet. 2018. PMID: 29264831

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