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Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation.
Lavaggi ML, Cabrera M, Aravena Mde L, Olea-Azar C, López de Ceráin A, Monge A, Pachón G, Cascante M, Bruno AM, Pietrasanta LI, González M, Cerecetto H. Lavaggi ML, et al. Among authors: cascante m. Bioorg Med Chem. 2010 Jun 15;18(12):4433-40. doi: 10.1016/j.bmc.2010.04.074. Epub 2010 Apr 26. Bioorg Med Chem. 2010. PMID: 20471844
Antitumoral effect of phenazine N5,N10-dioxide derivatives on Caco-2 cells.
Pachón OG, Azqueta A, Lavaggi ML, López de Cerain A, Creppy E, Collins A, Cerecetto H, González M, Centelles JJ, Cascante M. Pachón OG, et al. Among authors: cascante m. Chem Res Toxicol. 2008 Aug;21(8):1578-85. doi: 10.1021/tx800032k. Epub 2008 Jun 14. Chem Res Toxicol. 2008. PMID: 18553946
Novel Phenazine 5,10-Dioxides Release OH in Simulated Hypoxia and Induce Reduction of Tumour Volume In Vivo.
Lavaggi ML, Cabrera M, Pintos C, Arredondo C, Pachón G, Rodríguez J, Raymondo S, Pacheco JP, Cascante M, Olea-Azar C, López de Ceráin A, Monge A, Cerecetto H, González M. Lavaggi ML, et al. Among authors: cascante m. ISRN Pharmacol. 2011;2011:314209. doi: 10.5402/2011/314209. Epub 2011 Jun 22. ISRN Pharmacol. 2011. PMID: 22084710 Free PMC article.
Pt(II) complexes with (N,N') or (C,N,E)(-) (E=N,S) ligands: cytotoxic studies, effect on DNA tertiary structure and structure-activity relationships.
Albert J, Bosque R, Crespo M, Granell J, López C, Cortés R, Gonzalez A, Quirante J, Calvis C, Messeguer R, Baldomà L, Badia J, Cascante M. Albert J, et al. Among authors: cascante m. Bioorg Med Chem. 2013 Jul 15;21(14):4210-7. doi: 10.1016/j.bmc.2013.05.005. Epub 2013 May 14. Bioorg Med Chem. 2013. PMID: 23735827
306 results