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Chiral NG-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity.
Bioorg Med Chem Lett. 2010 May 15;20(10):3173-6. doi: 10.1016/j.bmcl.2010.03.082. Epub 2010 Mar 27.
Bioorg Med Chem Lett. 2010.
PMID: 20409707
N(G)-acylated aminothiazolylpropylguanidines as potent and selective histamine H(2) receptor agonists.
Kraus A, Ghorai P, Birnkammer T, Schnell D, Elz S, Seifert R, Dove S, Bernhardt G, Buschauer A.
Kraus A, et al. Among authors: birnkammer t.
ChemMedChem. 2009 Feb;4(2):232-40. doi: 10.1002/cmdc.200800296.
ChemMedChem. 2009.
PMID: 19072936
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The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H₂ receptor agonists.
Birnkammer T, Spickenreither A, Brunskole I, Lopuch M, Kagermeier N, Bernhardt G, Dove S, Seifert R, Elz S, Buschauer A.
Birnkammer T, et al.
J Med Chem. 2012 Feb 9;55(3):1147-60. doi: 10.1021/jm201128q. Epub 2012 Jan 25.
J Med Chem. 2012.
PMID: 22216892
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