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1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists.
Zhou N, Polozov AM, O'Connell M, Burgeson J, Yu P, Zeller W, Zhang J, Onua E, Ramirez J, Palsdottir GA, Halldorsdottir GV, Andresson T, Kiselyov AS, Gurney M, Singh J. Zhou N, et al. Among authors: onua e. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2658-64. doi: 10.1016/j.bmcl.2010.02.028. Epub 2010 Feb 25. Bioorg Med Chem Lett. 2010. PMID: 20303752
Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding.
Singh J, Zeller W, Zhou N, Hategen G, Mishra R, Polozov A, Yu P, Onua E, Zhang J, Zembower D, Kiselyov A, Ramírez JL, Sigthorsson G, Bjornsson JM, Thorsteinsdottir M, Andrésson T, Bjarnadottir M, Magnusson O, Fabre JE, Stefansson K, Gurney ME. Singh J, et al. Among authors: onua e. ACS Chem Biol. 2009 Feb 20;4(2):115-26. doi: 10.1021/cb8002094. ACS Chem Biol. 2009. PMID: 19193156
Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that does not prolong bleeding.
Singh J, Zeller W, Zhou N, Hategan G, Mishra RK, Polozov A, Yu P, Onua E, Zhang J, Ramírez JL, Sigthorsson G, Thorsteinnsdottir M, Kiselyov AS, Zembower DE, Andrésson T, Gurney ME. Singh J, et al. Among authors: onua e. J Med Chem. 2010 Jan 14;53(1):18-36. doi: 10.1021/jm9005912. J Med Chem. 2010. PMID: 19957930
Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.
Sandanayaka V, Mamat B, Mishra RK, Winger J, Krohn M, Zhou LM, Keyvan M, Enache L, Sullins D, Onua E, Zhang J, Halldorsdottir G, Sigthorsdottir H, Thorlaksdottir A, Sigthorsson G, Thorsteinnsdottir M, Davies DR, Stewart LJ, Zembower DE, Andresson T, Kiselyov AS, Singh J, Gurney ME. Sandanayaka V, et al. Among authors: onua e. J Med Chem. 2010 Jan 28;53(2):573-85. doi: 10.1021/jm900838g. J Med Chem. 2010. PMID: 19950900
Oral toxicity and pharmacokinetic studies of SHetA2, a new chemopreventive agent, in rats and dogs.
Kabirov KK, Kapetanovic IM, Benbrook DM, Dinger N, Mankovskaya I, Zakharov A, Detrisac C, Pereira M, Martín-Jiménez T, Onua E, Banerjee A, van Breemen RB, Nikolić D, Chen L, Lyubimov AV. Kabirov KK, et al. Among authors: onua e. Drug Chem Toxicol. 2013 Jul;36(3):284-95. doi: 10.3109/01480545.2012.710632. Epub 2012 Sep 5. Drug Chem Toxicol. 2013. PMID: 22947079