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Optogenetic stimulation of dynorphinergic neurons within the dorsal raphe activate kappa opioid receptors in the ventral tegmental area and ablation of dorsal raphe prodynorphin or kappa receptors in dopamine neurons blocks stress potentiation of cocaine reward.
Abraham AD, Casello SM, Land BB, Chavkin C. Abraham AD, et al. Addict Neurosci. 2022 Mar;1:100005. doi: 10.1016/j.addicn.2022.100005. Epub 2022 Jan 25. Addict Neurosci. 2022. PMID: 36176476 Free PMC article.
Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L.
Prigaro BJ, Esquer H, Zhou Q, Pike LA, Awolade P, Lai XH, Abraham AD, Abbott JM, Matter B, Kompella UB, Messersmith WA, Gustafson DL, LaBarbera DV. Prigaro BJ, et al. Among authors: abraham ad. J Med Chem. 2022 Mar 10;65(5):3943-3961. doi: 10.1021/acs.jmedchem.1c01778. Epub 2022 Feb 22. J Med Chem. 2022. PMID: 35192363 Free PMC article.
Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT1B receptors.
Fontaine HM, Silva PR, Neiswanger C, Tran R, Abraham AD, Land BB, Neumaier JF, Chavkin C. Fontaine HM, et al. Among authors: abraham ad. Neuropsychopharmacology. 2022 Mar;47(4):891-901. doi: 10.1038/s41386-021-01178-0. Epub 2021 Sep 25. Neuropsychopharmacology. 2022. PMID: 34564712 Free PMC article.
58 results