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Page 1
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.
Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, Wu J, Modrusan Z, Stinson J, Eby M, Yue P, Kaminker JS, de Sauvage FJ, Backer JM, Seshagiri S. Jaiswal BS, et al. Among authors: backer jm. Cancer Cell. 2009 Dec 8;16(6):463-74. doi: 10.1016/j.ccr.2009.10.016. Cancer Cell. 2009. PMID: 19962665 Free PMC article.
Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.
Wu H, Shekar SC, Flinn RJ, El-Sibai M, Jaiswal BS, Sen KI, Janakiraman V, Seshagiri S, Gerfen GJ, Girvin ME, Backer JM. Wu H, et al. Among authors: backer jm. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20258-63. doi: 10.1073/pnas.0902369106. Epub 2009 Nov 13. Proc Natl Acad Sci U S A. 2009. PMID: 19915146 Free PMC article.
A beta version of life: p110β takes center stage.
Dbouk HA, Backer JM. Dbouk HA, et al. Among authors: backer jm. Oncotarget. 2010 Dec;1(8):729-733. doi: 10.18632/oncotarget.207. Oncotarget. 2010. PMID: 21321382 Free PMC article. Review.
G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.
Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM. Dbouk HA, et al. Among authors: backer jm. Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264. Sci Signal. 2012. PMID: 23211529 Free PMC article.
PI3Kβ downstream of GPCRs - crucial partners in oncogenesis.
Dbouk HA, Vadas O, Williams RL, Backer JM. Dbouk HA, et al. Among authors: backer jm. Oncotarget. 2012 Dec;3(12):1485-6. doi: 10.18632/oncotarget.787. Oncotarget. 2012. PMID: 23328076 Free PMC article. No abstract available.
232 results