Fox KR - Search Results

1

Response of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer.

Doyle M, Feuerbaum EA, Fox KR, Hinds J, Thurston DE, Taylor PW. Doyle M, et al. Among authors: fox kr. J Antimicrob Chemother. 2009 Nov;64(5):949-59. doi: 10.1093/jac/dkp325. Epub 2009 Sep 10. J Antimicrob Chemother. 2009. PMID: 19744983 Free PMC article.

2

Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates.

Rahman KM, Rosado H, Moreira JB, Feuerbaum EA, Fox KR, Stecher E, Howard PW, Gregson SJ, James CH, de la Fuente M, Waldron DE, Thurston DE, Taylor PW. Rahman KM, et al. Among authors: fox kr. J Antimicrob Chemother. 2012 Jul;67(7):1683-96. doi: 10.1093/jac/dks127. Epub 2012 Apr 30. J Antimicrob Chemother. 2012. PMID: 22547662 Free PMC article.

3

Sequence-selective binding of C8-conjugated pyrrolobenzodiazepines (PBDs) to DNA.

Basher MA, Rahman KM, Jackson PJM, Thurston DE, Fox KR. Basher MA, et al. Among authors: fox kr. Biophys Chem. 2017 Nov;230:53-61. doi: 10.1016/j.bpc.2017.08.006. Epub 2017 Sep 1. Biophys Chem. 2017. PMID: 28941814

4

DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies.

Procopiou G, Jackson PJM, di Mascio D, Auer JL, Pepper C, Rahman KM, Fox KR, Thurston DE. Procopiou G, et al. Among authors: fox kr. Commun Biol. 2022 Jul 29;5(1):741. doi: 10.1038/s42003-022-03633-0. Commun Biol. 2022. PMID: 35906376 Free PMC article.

5

Biaryl polyamides as a new class of DNA quadruplex-binding ligands.

Rahman KM, Reszka AP, Gunaratnam M, Haider SM, Howard PW, Fox KR, Neidle S, Thurston DE. Rahman KM, et al. Among authors: fox kr. Chem Commun (Camb). 2009 Jul 21;(27):4097-9. doi: 10.1039/b902359c. Epub 2009 Jun 5. Chem Commun (Camb). 2009. PMID: 19568645

6

GC-targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models.

Rahman KM, Jackson PJ, James CH, Basu BP, Hartley JA, de la Fuente M, Schatzlein A, Robson M, Pedley RB, Pepper C, Fox KR, Howard PW, Thurston DE. Rahman KM, et al. Among authors: fox kr. J Med Chem. 2013 Apr 11;56(7):2911-35. doi: 10.1021/jm301882a. Epub 2013 Mar 21. J Med Chem. 2013. PMID: 23514599

7

A novel series of DNA triple helix-binding ligands.

Fox KR, Thurston DE, Jenkins TC, Varvaresou A, Tsotinis A, Siatra-Papastaikoudi T. Fox KR, et al. Biochem Biophys Res Commun. 1996 Jul 25;224(3):717-20. doi: 10.1006/bbrc.1996.1089. Biochem Biophys Res Commun. 1996. PMID: 8713112

8

DNA sequence-selective C8-linked pyrrolobenzodiazepine-heterocyclic polyamide conjugates show anti-tubercular-specific activities.

Brucoli F, Guzman JD, Basher MA, Evangelopoulos D, McMahon E, Munshi T, McHugh TD, Fox KR, Bhakta S. Brucoli F, et al. Among authors: fox kr. J Antibiot (Tokyo). 2016 Dec;69(12):843-849. doi: 10.1038/ja.2016.43. Epub 2016 May 11. J Antibiot (Tokyo). 2016. PMID: 27168314

9

Synthesis, anti-mycobacterial activity and DNA sequence-selectivity of a library of biaryl-motifs containing polyamides.

Brucoli F, Guzman JD, Maitra A, James CH, Fox KR, Bhakta S. Brucoli F, et al. Among authors: fox kr. Bioorg Med Chem. 2015 Jul 1;23(13):3705-11. doi: 10.1016/j.bmc.2015.04.001. Epub 2015 Apr 8. Bioorg Med Chem. 2015. PMID: 25921267

10

DNA sequence preferences of several AT-selective minor groove binding ligands.

Abu-Daya A, Brown PM, Fox KR. Abu-Daya A, et al. Among authors: fox kr. Nucleic Acids Res. 1995 Sep 11;23(17):3385-92. doi: 10.1093/nar/23.17.3385. Nucleic Acids Res. 1995. PMID: 7567447 Free PMC article.

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