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5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV.
Starr JT, Sciotti RJ, Hanna DL, Huband MD, Mullins LM, Cai H, Gage JW, Lockard M, Rauckhorst MR, Owen RM, Lall MS, Tomilo M, Chen H, McCurdy SP, Barbachyn MR. Starr JT, et al. Among authors: rauckhorst mr. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5302-6. doi: 10.1016/j.bmcl.2009.07.141. Epub 2009 Aug 3. Bioorg Med Chem Lett. 2009. PMID: 19683922
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
Starr J, Brown MF, Aschenbrenner L, Caspers N, Che Y, Gerstenberger BS, Huband M, Knafels JD, Lemmon MM, Li C, McCurdy SP, McElroy E, Rauckhorst MR, Tomaras AP, Young JA, Zaniewski RP, Shanmugasundaram V, Han S. Starr J, et al. Among authors: rauckhorst mr. J Med Chem. 2014 May 8;57(9):3845-55. doi: 10.1021/jm500219c. Epub 2014 Apr 21. J Med Chem. 2014. PMID: 24694215
One-pot synthesis of N-arylpyrazoles from arylhalides.
Gerstenberger BS, Rauckhorst MR, Starr JT. Gerstenberger BS, et al. Among authors: rauckhorst mr. Org Lett. 2009 May 21;11(10):2097-100. doi: 10.1021/ol900515a. Org Lett. 2009. PMID: 19385606
The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents.
Murphy ST, Case HL, Ellsworth E, Hagen S, Huband M, Joannides T, Limberakis C, Marotti KR, Ottolini AM, Rauckhorst M, Starr J, Stier M, Taylor C, Zhu T, Blaser A, Denny WA, Lu GL, Smaill JB, Rivault F. Murphy ST, et al. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2150-5. doi: 10.1016/j.bmcl.2007.01.090. Epub 2007 Feb 2. Bioorg Med Chem Lett. 2007. PMID: 17303420