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Extended anti-inflammatory action of a degradation-resistant mutant of cell-penetrating suppressor of cytokine signaling 3.
Fletcher TC, DiGiandomenico A, Hawiger J. Fletcher TC, et al. Among authors: hawiger j. J Biol Chem. 2010 Jun 11;285(24):18727-36. doi: 10.1074/jbc.M109.095216. Epub 2010 Apr 16. J Biol Chem. 2010. PMID: 20400504 Free PMC article.
Previously, we developed an intracellular protein therapy that uses a recombinant cell-penetrating form of SOCS3 (CP-SOCS3) to inhibit the JAK/STAT pathway and prevent cytokine-mediated lethal inflammation and apoptosis of the liver (Jo, D., Liu, D., Yao, S., Collins, R. D., and …
Previously, we developed an intracellular protein therapy that uses a recombinant cell-penetrating form of SOCS3 (CP-SOCS3) to inhibit the J …
The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli.
Qiao H, Liu Y, Veach RA, Wylezinski L, Hawiger J. Qiao H, et al. Among authors: hawiger j. J Biol Chem. 2014 Aug 8;289(32):21973-83. doi: 10.1074/jbc.M114.588723. Epub 2014 Jun 23. J Biol Chem. 2014. PMID: 24958727 Free PMC article.
Previously, we reported that BCL10 in immune cells is targeted by the "death" adaptor CRADD/RAIDD (CRADD), which negatively regulates nuclear factor kappaB (NFkappaB)-dependent cytokine and chemokine expression in T cells (Lin, Q., Liu, Y., Moore, D. J., Elizer, S. K., Vea …
Previously, we reported that BCL10 in immune cells is targeted by the "death" adaptor CRADD/RAIDD (CRADD), which negatively regulates nuclea …
143 results