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Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure.
Hullin R, Matthes J, von Vietinghoff S, Bodi I, Rubio M, D'Souza K, Friedrich Khan I, Rottländer D, Hoppe UC, Mohacsi P, Schmitteckert E, Gilsbach R, Bünemann M, Hein L, Schwartz A, Herzig S. Hullin R, et al. Among authors: hoppe uc. PLoS One. 2007 Mar 14;2(3):e292. doi: 10.1371/journal.pone.0000292. PLoS One. 2007. PMID: 17356701 Free PMC article.
Exclusion of alternative exon 33 of CaV1.2 calcium channels in heart is proarrhythmogenic.
Li G, Wang J, Liao P, Bartels P, Zhang H, Yu D, Liang MC, Poh KK, Yu CY, Jiang F, Yong TF, Wong YP, Hu Z, Huang H, Zhang G, Galupo MJ, Bian JS, Ponniah S, Trasti SL, See K, Foo R, Hoppe UC, Herzig S, Soong TW. Li G, et al. Among authors: hoppe uc. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4288-E4295. doi: 10.1073/pnas.1617205114. Epub 2017 May 10. Proc Natl Acad Sci U S A. 2017. PMID: 28490495 Free PMC article.
381 results