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Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT. James RG, et al. Among authors: major mb. Sci Signal. 2009 May 26;2(72):ra25. doi: 10.1126/scisignal.2000230. Sci Signal. 2009. PMID: 19471023 Free PMC article.
Beta-catenin gets jaded and von Hippel-Lindau is to blame.
Berndt JD, Moon RT, Major MB. Berndt JD, et al. Among authors: major mb. Trends Biochem Sci. 2009 Mar;34(3):101-4. doi: 10.1016/j.tibs.2008.12.002. Epub 2009 Feb 11. Trends Biochem Sci. 2009. PMID: 19217300
WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.
James RG, Davidson KC, Bosch KA, Biechele TL, Robin NC, Taylor RJ, Major MB, Camp ND, Fowler K, Martins TJ, Moon RT. James RG, et al. Among authors: major mb. PLoS One. 2012;7(12):e50457. doi: 10.1371/journal.pone.0050457. Epub 2012 Dec 5. PLoS One. 2012. PMID: 23227175 Free PMC article.
Small-molecule synergist of the Wnt/beta-catenin signaling pathway.
Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S. Zhang Q, et al. Among authors: major mb. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7444-8. doi: 10.1073/pnas.0702136104. Epub 2007 Apr 25. Proc Natl Acad Sci U S A. 2007. PMID: 17460038 Free PMC article.
Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model.
Chien AJ, Moore EC, Lonsdorf AS, Kulikauskas RM, Rothberg BG, Berger AJ, Major MB, Hwang ST, Rimm DL, Moon RT. Chien AJ, et al. Among authors: major mb. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1193-8. doi: 10.1073/pnas.0811902106. Epub 2009 Jan 14. Proc Natl Acad Sci U S A. 2009. PMID: 19144919 Free PMC article.
93 results