Al-Abed Y - Search Results

1

The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt.

Maksimovic-Ivanic D, Mijatovic S, Miljkovic D, Harhaji-Trajkovic L, Timotijevic G, Mojic M, Dabideen D, Cheng KF, McCubrey JA, Mangano K, Al-Abed Y, Libra M, Garotta G, Stosic-Grujicic S, Nicoletti F. Maksimovic-Ivanic D, et al. Mol Cancer Ther. 2009 May;8(5):1169-78. doi: 10.1158/1535-7163.MCT-08-0998. Epub 2009 May 5. Mol Cancer Ther. 2009. PMID: 19417156

2

Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes.

Cvetkovic I, Al-Abed Y, Miljkovic D, Maksimovic-Ivanic D, Roth J, Bacher M, Lan HY, Nicoletti F, Stosic-Grujicic S. Cvetkovic I, et al. Endocrinology. 2005 Jul;146(7):2942-51. doi: 10.1210/en.2004-1393. Epub 2005 Mar 24. Endocrinology. 2005. PMID: 15790730

3

ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis.

Al-Abed Y, Dabideen D, Aljabari B, Valster A, Messmer D, Ochani M, Tanovic M, Ochani K, Bacher M, Nicoletti F, Metz C, Pavlov VA, Miller EJ, Tracey KJ. Al-Abed Y, et al. J Biol Chem. 2005 Nov 4;280(44):36541-4. doi: 10.1074/jbc.C500243200. Epub 2005 Aug 22. J Biol Chem. 2005. PMID: 16115897 Free article.

4

Macrophage migration inhibitory factor (MIF) seems crucially involved in Guillain-Barré syndrome and experimental allergic neuritis.

Nicoletti F, Créange A, Orlikowski D, Bolgert F, Mangano K, Metz C, Di Marco R, Al Abed Y. Nicoletti F, et al. J Neuroimmunol. 2005 Nov;168(1-2):168-74. doi: 10.1016/j.jneuroim.2005.07.019. J Neuroimmunol. 2005. PMID: 16171874 Clinical Trial.

5

Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity.

Cheng KF, Al-Abed Y. Cheng KF, et al. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3376-9. doi: 10.1016/j.bmcl.2006.04.038. Epub 2006 May 6. Bioorg Med Chem Lett. 2006. PMID: 16682188

6

A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice.

Stosic-Grujicic S, Cvetkovic I, Mangano K, Fresta M, Maksimovic-Ivanic D, Harhaji L, Popadic D, Momcilovic M, Miljkovic D, Kim J, Al-Abed Y, Nicoletti F. Stosic-Grujicic S, et al. J Pharmacol Exp Ther. 2007 Mar;320(3):1038-49. doi: 10.1124/jpet.106.109272. Epub 2006 Dec 5. J Pharmacol Exp Ther. 2007. PMID: 17148780

7

Phenolic hydrazones are potent inhibitors of macrophage migration inhibitory factor proinflammatory activity and survival improving agents in sepsis.

Dabideen DR, Cheng KF, Aljabari B, Miller EJ, Pavlov VA, Al-Abed Y. Dabideen DR, et al. J Med Chem. 2007 Apr 19;50(8):1993-7. doi: 10.1021/jm061477+. Epub 2007 Mar 27. J Med Chem. 2007. PMID: 17385848 Free PMC article.

8

In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models.

Stojanovic I, Cuzzocrea S, Mangano K, Mazzon E, Miljkovic D, Wang M, Donia M, Al Abed Y, Kim J, Nicoletti F, Stosic-Grujicic S, Claesson M. Stojanovic I, et al. Clin Immunol. 2007 Jun;123(3):311-23. doi: 10.1016/j.clim.2007.03.004. Epub 2007 Apr 20. Clin Immunol. 2007. PMID: 17449326

9

Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.

Crichlow GV, Cheng KF, Dabideen D, Ochani M, Aljabari B, Pavlov VA, Miller EJ, Lolis E, Al-Abed Y. Crichlow GV, et al. J Biol Chem. 2007 Aug 10;282(32):23089-95. doi: 10.1074/jbc.M701825200. Epub 2007 May 25. J Biol Chem. 2007. PMID: 17526494 Free PMC article.

10

Macrophage migration inhibitory factor (MIF) is necessary for progression of autoimmune diabetes mellitus.

Stosic-Grujicic S, Stojanovic I, Maksimovic-Ivanic D, Momcilovic M, Popadic D, Harhaji L, Miljkovic D, Metz C, Mangano K, Papaccio G, Al-Abed Y, Nicoletti F. Stosic-Grujicic S, et al. J Cell Physiol. 2008 Jun;215(3):665-75. doi: 10.1002/jcp.21346. J Cell Physiol. 2008. PMID: 18064633

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