Cai H - Search Results

1

Assessment of the renal toxicity of novel anti-inflammatory compounds using cynomolgus monkey and human kidney cells.

Cai H, Agrawal AK, Putt DA, Hashim M, Reddy A, Brodfuehrer J, Surendran N, Lash LH. Cai H, et al. Toxicology. 2009 Apr 5;258(1):56-63. doi: 10.1016/j.tox.2009.01.006. Toxicology. 2009. PMID: 19378467

2

Membrane transport function in primary cultures of human proximal tubular cells.

Lash LH, Putt DA, Cai H. Lash LH, et al. Among authors: cai h. Toxicology. 2006 Dec 7;228(2-3):200-18. doi: 10.1016/j.tox.2006.08.035. Epub 2006 Sep 1. Toxicology. 2006. PMID: 16997449

3

Drug metabolism enzyme expression and activity in primary cultures of human proximal tubular cells.

Lash LH, Putt DA, Cai H. Lash LH, et al. Among authors: cai h. Toxicology. 2008 Feb 3;244(1):56-65. doi: 10.1016/j.tox.2007.10.022. Epub 2007 Nov 4. Toxicology. 2008. PMID: 18055091 Free PMC article.

We previously catalogued expression and activity of organic anion and cation, amino acid, and peptide transporters in primary cultures of human proximal tubular (hPT) cells to establish them as a cellular model to study drug transport in the human kidney [Lash, L.H., Putt, …

We previously catalogued expression and activity of organic anion and cation, amino acid, and peptide transporters in primary cultures of hu …

4

Validation of a semi-automated human hepatocyte assay for the determination and prediction of intrinsic clearance in discovery.

Reddy A, Heimbach T, Freiwald S, Smith D, Winters R, Michael S, Surendran N, Cai H. Reddy A, et al. Among authors: cai h. J Pharm Biomed Anal. 2005 Feb 23;37(2):319-26. doi: 10.1016/j.jpba.2004.09.030. J Pharm Biomed Anal. 2005. PMID: 15708673

5

A novel method for assessing inhibition of ibuprofen chiral inversion and its application in drug discovery.

Reddy A, Hashim M, Wang Z, Penn L, Stankovic CJ, Burdette D, Surendran N, Cai H. Reddy A, et al. Among authors: cai h. Int J Pharm. 2007 Apr 20;335(1-2):63-69. doi: 10.1016/j.ijpharm.2006.11.006. Epub 2006 Dec 14. Int J Pharm. 2007. PMID: 17174047

6

Evaluation of an integrated in vitro-in silico PBPK (physiologically based pharmacokinetic) model to provide estimates of human bioavailability.

Cai H, Stoner C, Reddy A, Freiwald S, Smith D, Winters R, Stankovic C, Surendran N. Cai H, et al. Int J Pharm. 2006 Feb 3;308(1-2):133-9. doi: 10.1016/j.ijpharm.2005.11.002. Epub 2005 Dec 13. Int J Pharm. 2006. PMID: 16352407

7

Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption.

Pfefferkorn JA, Larsen SD, Van Huis C, Sorenson R, Barton T, Winters T, Auerbach B, Wu C, Wolfram TJ, Cai H, Welch K, Esmaiel N, Davis J, Bousley R, Olsen K, Mueller SB, Mertz T. Pfefferkorn JA, et al. Among authors: cai h. Bioorg Med Chem Lett. 2008 Jan 15;18(2):546-53. doi: 10.1016/j.bmcl.2007.11.083. Epub 2007 Nov 28. Bioorg Med Chem Lett. 2008. PMID: 18063367

8

In vitro ADME phenotyping in drug discovery: current challenges and future solutions.

Williams JA, Bauman J, Cai H, Conlon K, Hansel S, Hurst S, Sadagopan N, Tugnait M, Zhang L, Sahi J. Williams JA, et al. Among authors: cai h. Curr Opin Drug Discov Devel. 2005 Jan;8(1):78-88. Curr Opin Drug Discov Devel. 2005. PMID: 15679175 Review.

9

A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation.

Cai H, Nguyen N, Peterkin V, Yang YS, Hotz K, La Placa DB, Chen S, Tukey RH, Stevens JC. Cai H, et al. Drug Metab Dispos. 2010 May;38(5):879-86. doi: 10.1124/dmd.109.030130. Epub 2010 Feb 2. Drug Metab Dispos. 2010. PMID: 20124398 Free PMC article.

10

Development of a liquid chromatography/mass spectrometry-based drug accumulation assay in Pseudomonas aeruginosa.

Cai H, Rose K, Liang LH, Dunham S, Stover C. Cai H, et al. Anal Biochem. 2009 Feb 15;385(2):321-5. doi: 10.1016/j.ab.2008.10.041. Epub 2008 Nov 5. Anal Biochem. 2009. PMID: 19032927

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