Brodfuehrer J - Search Results

1

Assessment of the renal toxicity of novel anti-inflammatory compounds using cynomolgus monkey and human kidney cells.

Cai H, Agrawal AK, Putt DA, Hashim M, Reddy A, Brodfuehrer J, Surendran N, Lash LH. Cai H, et al. Among authors: brodfuehrer j. Toxicology. 2009 Apr 5;258(1):56-63. doi: 10.1016/j.tox.2009.01.006. Toxicology. 2009. PMID: 19378467

2

Integrated oral bioavailability projection using in vitro screening data as a selection tool in drug discovery.

Stoner CL, Cleton A, Johnson K, Oh DM, Hallak H, Brodfuehrer J, Surendran N, Han HK. Stoner CL, et al. Among authors: brodfuehrer j. Int J Pharm. 2004 Jan 9;269(1):241-9. doi: 10.1016/j.ijpharm.2003.09.006. Int J Pharm. 2004. PMID: 14698595

3

Implementation of an ADME enabling selection and visualization tool for drug discovery.

Stoner CL, Gifford E, Stankovic C, Lepsy CS, Brodfuehrer J, Prasad JV, Surendran N. Stoner CL, et al. Among authors: brodfuehrer j. J Pharm Sci. 2004 May;93(5):1131-41. doi: 10.1002/jps.20020. J Pharm Sci. 2004. PMID: 15067690

4

Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans.

Hurst S, Loi CM, Brodfuehrer J, El-Kattan A. Hurst S, et al. Among authors: brodfuehrer j. Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):469-89. doi: 10.1517/17425225.3.4.469. Expert Opin Drug Metab Toxicol. 2007. PMID: 17696800 Review.

5

Understanding the clinical pharmacokinetics of a GABAA partial agonist by application of in vitro tools.

Sawant AD, Miller EL, Duignan DB, Brodfuehrer J, Winter SM, Nelson FR, Kamel A, Obach RS, Vaz AD. Sawant AD, et al. Among authors: brodfuehrer j. Xenobiotica. 2010 Jul;40(7):476-84. doi: 10.3109/00498254.2010.481057. Xenobiotica. 2010. PMID: 20429841

6

Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.

Poel TJ, Thomas RC, Adams WJ, Aristoff PA, Barbachyn MR, Boyer FE, Brieland J, Brideau R, Brodfuehrer J, Brown AP, Choy AL, Dermyer M, Dority M, Ford CW, Gadwood RC, Hanna D, Hongliang C, Huband MD, Huber C, Kelly R, Kim JY, Martin JP Jr, Pagano PJ, Ross D, Skerlos L, Sulavik MC, Zhu T, Zurenko GE, Prasad JV. Poel TJ, et al. Among authors: brodfuehrer j. J Med Chem. 2007 Nov 29;50(24):5886-9. doi: 10.1021/jm070708p. Epub 2007 Nov 8. J Med Chem. 2007. PMID: 17988109

7

The use of 1-aminobenzotriazole in differentiating the role of CYP-mediated first pass metabolism and absorption in limiting drug oral bioavailability: a case study.

El-Kattan AF, Poe J, Buchholz L, Thomas HV, Brodfuehrer J, Clark A. El-Kattan AF, et al. Among authors: brodfuehrer j. Drug Metab Lett. 2008 Apr;2(2):120-4. doi: 10.2174/187231208784041004. Drug Metab Lett. 2008. PMID: 19356080

8

4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: the effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters.

Hagen SE, Domagala J, Gajda C, Lovdahl M, Tait BD, Wise E, Holler T, Hupe D, Nouhan C, Urumov A, Zeikus G, Zeikus E, Lunney EA, Pavlovsky A, Gracheck SJ, Saunders J, VanderRoest S, Brodfuehrer J. Hagen SE, et al. Among authors: brodfuehrer j. J Med Chem. 2001 Jul 5;44(14):2319-32. doi: 10.1021/jm0003844. J Med Chem. 2001. PMID: 11428926

9

Pharmacokinetics of clinafloxacin enantiomers in humans.

Humphrey GH, Shapiro MA, Randinitis EJ, Guttendorf RJ, Brodfuehrer JI. Humphrey GH, et al. Among authors: brodfuehrer ji. J Clin Pharmacol. 1999 Nov;39(11):1143-50. J Clin Pharmacol. 1999. PMID: 10579144

10

Current advances in delivery of biotherapeutics across the blood-brain barrier.

Rajadhyaksha M, Boyden T, Liras J, El-Kattan A, Brodfuehrer J. Rajadhyaksha M, et al. Among authors: brodfuehrer j. Curr Drug Discov Technol. 2011 Jun;8(2):87-101. doi: 10.2174/157016311795563866. Curr Drug Discov Technol. 2011. PMID: 21513485 Review.

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