Cai H - Search Results

1

Structure-activity relationship (SAR): effort towards blocking N-glucuronidation of indazoles (PF-03376056) by human UGT1A enzymes.

Rose K, Yang YS, Sciotti R, Cai H. Rose K, et al. Among authors: cai h. Drug Metab Lett. 2009 Jan;3(1):28-34. doi: 10.2174/187231209787176371. Drug Metab Lett. 2009. PMID: 19356114

2

A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation.

Cai H, Nguyen N, Peterkin V, Yang YS, Hotz K, La Placa DB, Chen S, Tukey RH, Stevens JC. Cai H, et al. Drug Metab Dispos. 2010 May;38(5):879-86. doi: 10.1124/dmd.109.030130. Epub 2010 Feb 2. Drug Metab Dispos. 2010. PMID: 20124398 Free PMC article.

3

5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV.

Starr JT, Sciotti RJ, Hanna DL, Huband MD, Mullins LM, Cai H, Gage JW, Lockard M, Rauckhorst MR, Owen RM, Lall MS, Tomilo M, Chen H, McCurdy SP, Barbachyn MR. Starr JT, et al. Among authors: cai h. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5302-6. doi: 10.1016/j.bmcl.2009.07.141. Epub 2009 Aug 3. Bioorg Med Chem Lett. 2009. PMID: 19683922

4

Development of a liquid chromatography/mass spectrometry-based drug accumulation assay in Pseudomonas aeruginosa.

Cai H, Rose K, Liang LH, Dunham S, Stover C. Cai H, et al. Anal Biochem. 2009 Feb 15;385(2):321-5. doi: 10.1016/j.ab.2008.10.041. Epub 2008 Nov 5. Anal Biochem. 2009. PMID: 19032927

5

Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption.

Pfefferkorn JA, Larsen SD, Van Huis C, Sorenson R, Barton T, Winters T, Auerbach B, Wu C, Wolfram TJ, Cai H, Welch K, Esmaiel N, Davis J, Bousley R, Olsen K, Mueller SB, Mertz T. Pfefferkorn JA, et al. Among authors: cai h. Bioorg Med Chem Lett. 2008 Jan 15;18(2):546-53. doi: 10.1016/j.bmcl.2007.11.083. Epub 2007 Nov 28. Bioorg Med Chem Lett. 2008. PMID: 18063367

6

A novel method for assessing inhibition of ibuprofen chiral inversion and its application in drug discovery.

Reddy A, Hashim M, Wang Z, Penn L, Stankovic CJ, Burdette D, Surendran N, Cai H. Reddy A, et al. Among authors: cai h. Int J Pharm. 2007 Apr 20;335(1-2):63-69. doi: 10.1016/j.ijpharm.2006.11.006. Epub 2006 Dec 14. Int J Pharm. 2007. PMID: 17174047

7

In vitro ADME phenotyping in drug discovery: current challenges and future solutions.

Williams JA, Bauman J, Cai H, Conlon K, Hansel S, Hurst S, Sadagopan N, Tugnait M, Zhang L, Sahi J. Williams JA, et al. Among authors: cai h. Curr Opin Drug Discov Devel. 2005 Jan;8(1):78-88. Curr Opin Drug Discov Devel. 2005. PMID: 15679175 Review.

8

Evaluation of an integrated in vitro-in silico PBPK (physiologically based pharmacokinetic) model to provide estimates of human bioavailability.

Cai H, Stoner C, Reddy A, Freiwald S, Smith D, Winters R, Stankovic C, Surendran N. Cai H, et al. Int J Pharm. 2006 Feb 3;308(1-2):133-9. doi: 10.1016/j.ijpharm.2005.11.002. Epub 2005 Dec 13. Int J Pharm. 2006. PMID: 16352407

9

Assessment of the renal toxicity of novel anti-inflammatory compounds using cynomolgus monkey and human kidney cells.

Cai H, Agrawal AK, Putt DA, Hashim M, Reddy A, Brodfuehrer J, Surendran N, Lash LH. Cai H, et al. Toxicology. 2009 Apr 5;258(1):56-63. doi: 10.1016/j.tox.2009.01.006. Toxicology. 2009. PMID: 19378467

10

Validation of a semi-automated human hepatocyte assay for the determination and prediction of intrinsic clearance in discovery.

Reddy A, Heimbach T, Freiwald S, Smith D, Winters R, Michael S, Surendran N, Cai H. Reddy A, et al. Among authors: cai h. J Pharm Biomed Anal. 2005 Feb 23;37(2):319-26. doi: 10.1016/j.jpba.2004.09.030. J Pharm Biomed Anal. 2005. PMID: 15708673

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