Leahy J - Search Results

1

Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass.

Delghingaro-Augusto V, Nolan CJ, Gupta D, Jetton TL, Latour MG, Peshavaria M, Madiraju SR, Joly E, Peyot ML, Prentki M, Leahy J. Delghingaro-Augusto V, et al. Among authors: leahy j. Diabetologia. 2009 Jun;52(6):1122-32. doi: 10.1007/s00125-009-1317-8. Epub 2009 Mar 18. Diabetologia. 2009. PMID: 19294363

2

Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

Nolan CJ, Leahy JL, Delghingaro-Augusto V, Moibi J, Soni K, Peyot ML, Fortier M, Guay C, Lamontagne J, Barbeau A, Przybytkowski E, Joly E, Masiello P, Wang S, Mitchell GA, Prentki M. Nolan CJ, et al. Among authors: leahy jl. Diabetologia. 2006 Sep;49(9):2120-30. doi: 10.1007/s00125-006-0305-5. Epub 2006 Jul 26. Diabetologia. 2006. PMID: 16868750

3

beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats.

Liu YQ, Jetton TL, Leahy JL. Liu YQ, et al. J Biol Chem. 2002 Oct 18;277(42):39163-8. doi: 10.1074/jbc.M207157200. Epub 2002 Jul 29. J Biol Chem. 2002. PMID: 12147706 Free article.

4

Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells.

Moibi JA, Gupta D, Jetton TL, Peshavaria M, Desai R, Leahy JL. Moibi JA, et al. Diabetes. 2007 Jan;56(1):88-95. doi: 10.2337/db06-0948. Diabetes. 2007. PMID: 17192469

5

In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter.

Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL. Gupta D, et al. J Biol Chem. 2008 Nov 21;283(47):32462-70. doi: 10.1074/jbc.M801813200. Epub 2008 Aug 21. J Biol Chem. 2008. PMID: 18718916 Free PMC article.

6

Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type 2 diabetes.

Gupta D, Peshavaria M, Monga N, Jetton TL, Leahy JL. Gupta D, et al. Diabetes. 2010 Jun;59(6):1445-50. doi: 10.2337/db09-1655. Epub 2010 Mar 23. Diabetes. 2010. PMID: 20332343 Free PMC article.

7

Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60 %-partial pancreatectomy rats.

Jetton TL, Liu YQ, Trotman WE, Nevin PW, Sun XJ, Leahy JL. Jetton TL, et al. Among authors: leahy jl. Diabetologia. 2001 Nov;44(11):2056-65. doi: 10.1007/s001250100011. Diabetologia. 2001. PMID: 11719838

8

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL. Jetton TL, et al. Among authors: leahy jl. Diabetes. 2005 Aug;54(8):2294-304. doi: 10.2337/diabetes.54.8.2294. Diabetes. 2005. PMID: 16046294

9

Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion.

Jetton TL, Everill B, Lausier J, Roskens V, Habibovic A, LaRock K, Gokin A, Peshavaria M, Leahy JL. Jetton TL, et al. Among authors: leahy jl. Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E679-87. doi: 10.1152/ajpendo.00569.2007. Epub 2008 Jan 29. Am J Physiol Endocrinol Metab. 2008. PMID: 18230696 Free article.

10

Peroxisome proliferator-activated receptor γ (PPARγ) and its target genes are downstream effectors of FoxO1 protein in islet β-cells: mechanism of β-cell compensation and failure.

Gupta D, Leahy AA, Monga N, Peshavaria M, Jetton TL, Leahy JL. Gupta D, et al. J Biol Chem. 2013 Aug 30;288(35):25440-25449. doi: 10.1074/jbc.M113.486852. Epub 2013 Jun 20. J Biol Chem. 2013. PMID: 23788637 Free PMC article.

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