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Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution.
Konstan MW, Davis PB, Wagener JS, Hilliard KA, Stern RC, Milgram LJ, Kowalczyk TH, Hyatt SL, Fink TL, Gedeon CR, Oette SM, Payne JM, Muhammad O, Ziady AG, Moen RC, Cooper MJ. Konstan MW, et al. Among authors: ziady ag. Hum Gene Ther. 2004 Dec;15(12):1255-69. doi: 10.1089/hum.2004.15.1255. Hum Gene Ther. 2004. PMID: 15684701 Clinical Trial.
Non-viral gene transfer therapy for cystic fibrosis.
Ziady AG, Davis PB, Konstan MW. Ziady AG, et al. Expert Opin Biol Ther. 2003 Jun;3(3):449-58. doi: 10.1517/14712598.3.3.449. Expert Opin Biol Ther. 2003. PMID: 12783613 Review.
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