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Synthesis of A83586C analogs with potent anticancer and beta-catenin/ TCF4/osteopontin inhibitory effects and insights into how A83586C modulates E2Fs and pRb.
Hale KJ, Manaviazar S, Lazarides L, George J, Walters MA, Cai J, Delisser VM, Bhatia GS, Peak SA, Dalby SM, Lefranc A, Chen YN, Wood AW, Crowe P, Erwin P, El-Tanani M. Hale KJ, et al. Among authors: bhatia gs. Org Lett. 2009 Feb 5;11(3):737-40. doi: 10.1021/ol802818f. Org Lett. 2009. PMID: 19175352
The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold.
Graczyk PP, Khan A, Bhatia GS, Palmer V, Medland D, Numata H, Oinuma H, Catchick J, Dunne A, Ellis M, Smales C, Whitfield J, Neame SJ, Shah B, Wilton D, Morgan L, Patel T, Chung R, Desmond H, Staddon JM, Sato N, Inoue A. Graczyk PP, et al. Among authors: bhatia gs. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4666-70. doi: 10.1016/j.bmcl.2005.07.076. Bioorg Med Chem Lett. 2005. PMID: 16153829
26 results