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Why lipids are important for Alzheimer disease?
Hirsch-Reinshagen V, Burgess BL, Wellington CL. Hirsch-Reinshagen V, et al. Among authors: wellington cl. Mol Cell Biochem. 2009 Jun;326(1-2):121-9. doi: 10.1007/s11010-008-0012-2. Epub 2008 Dec 31. Mol Cell Biochem. 2009. PMID: 19116777
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain.
Hirsch-Reinshagen V, Zhou S, Burgess BL, Bernier L, McIsaac SA, Chan JY, Tansley GH, Cohn JS, Hayden MR, Wellington CL. Hirsch-Reinshagen V, et al. Among authors: wellington cl. J Biol Chem. 2004 Sep 24;279(39):41197-207. doi: 10.1074/jbc.M407962200. Epub 2004 Jul 21. J Biol Chem. 2004. PMID: 15269218 Free article.
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.
Hirsch-Reinshagen V, Maia LF, Burgess BL, Blain JF, Naus KE, McIsaac SA, Parkinson PF, Chan JY, Tansley GH, Hayden MR, Poirier J, Van Nostrand W, Wellington CL. Hirsch-Reinshagen V, et al. Among authors: wellington cl. J Biol Chem. 2005 Dec 30;280(52):43243-56. doi: 10.1074/jbc.M508781200. Epub 2005 Oct 5. J Biol Chem. 2005. PMID: 16207707 Free article.
24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.
Abildayeva K, Jansen PJ, Hirsch-Reinshagen V, Bloks VW, Bakker AH, Ramaekers FC, de Vente J, Groen AK, Wellington CL, Kuipers F, Mulder M. Abildayeva K, et al. Among authors: wellington cl. J Biol Chem. 2006 May 5;281(18):12799-808. doi: 10.1074/jbc.M601019200. Epub 2006 Mar 8. J Biol Chem. 2006. PMID: 16524875 Free article.
Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma.
Burgess BL, McIsaac SA, Naus KE, Chan JY, Tansley GH, Yang J, Miao F, Ross CJ, van Eck M, Hayden MR, van Nostrand W, St George-Hyslop P, Westaway D, Wellington CL. Burgess BL, et al. Among authors: wellington cl. Neurobiol Dis. 2006 Oct;24(1):114-27. doi: 10.1016/j.nbd.2006.06.007. Epub 2006 Aug 8. Neurobiol Dis. 2006. PMID: 16899370
The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein.
Tansley GH, Burgess BL, Bryan MT, Su Y, Hirsch-Reinshagen V, Pearce J, Chan JY, Wilkinson A, Evans J, Naus KE, McIsaac S, Bromley K, Song W, Yang HC, Wang N, DeMattos RB, Wellington CL. Tansley GH, et al. Among authors: wellington cl. J Lipid Res. 2007 May;48(5):1022-34. doi: 10.1194/jlr.M600542-JLR200. Epub 2007 Feb 10. J Lipid Res. 2007. PMID: 17293612 Free article.
157 results