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Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.
Christiansen E, Hansen SV, Urban C, Hudson BD, Wargent ET, Grundmann M, Jenkins L, Zaibi M, Stocker CJ, Ullrich S, Kostenis E, Kassack MU, Milligan G, Cawthorne MA, Ulven T. Christiansen E, et al. Among authors: ullrich s. ACS Med Chem Lett. 2013 May 9;4(5):441-445. doi: 10.1021/ml4000673. Epub 2013 Apr 8. ACS Med Chem Lett. 2013. PMID: 23687558 Free PMC article.
Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469.
Christiansen E, Due-Hansen ME, Urban C, Merten N, Pfleiderer M, Karlsen KK, Rasmussen SS, Steensgaard M, Hamacher A, Schmidt J, Drewke C, Petersen RK, Kristiansen K, Ullrich S, Kostenis E, Kassack MU, Ulven T. Christiansen E, et al. Among authors: ullrich s. ACS Med Chem Lett. 2010 Jul 2;1(7):345-9. doi: 10.1021/ml100106c. eCollection 2010 Oct 14. ACS Med Chem Lett. 2010. PMID: 24900217 Free PMC article.
Mice Lacking Free Fatty Acid Receptor 1 (GPR40/FFAR1) are Protected Against Conjugated Linoleic Acid-Induced Fatty Liver but Develop Inflammation and Insulin Resistance in the Brain.
Sartorius T, Drescher A, Panse M, Lastovicka P, Peter A, Weigert C, Kostenis E, Ullrich S, Häring HU. Sartorius T, et al. Among authors: ullrich s. Cell Physiol Biochem. 2015;35(6):2272-84. doi: 10.1159/000374031. Epub 2015 Apr 13. Cell Physiol Biochem. 2015. PMID: 25895678 Free article.
Activation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) by free fatty acid receptor 1 (FFAR1/GPR40) protects from palmitate-induced beta cell death, but plays no role in insulin secretion.
Panse M, Gerst F, Kaiser G, Teutsch CA, Dölker R, Wagner R, Häring HU, Ullrich S. Panse M, et al. Among authors: ullrich s. Cell Physiol Biochem. 2015;35(4):1537-45. doi: 10.1159/000373969. Epub 2015 Mar 12. Cell Physiol Biochem. 2015. PMID: 25792236 Free article.
640 results