Kassack MU - Search Results

1

Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.

Christiansen E, Urban C, Merten N, Liebscher K, Karlsen KK, Hamacher A, Spinrath A, Bond AD, Drewke C, Ullrich S, Kassack MU, Kostenis E, Ulven T. Christiansen E, et al. Among authors: kassack mu. J Med Chem. 2008 Nov 27;51(22):7061-4. doi: 10.1021/jm8010178. J Med Chem. 2008. PMID: 18947221

2

Dibenzazecine compounds with a novel dopamine/5HT2A receptor profile and 3D-QSAR analysis.

Hamacher A, Weigt M, Wiese M, Hoefgen B, Lehmann J, Kassack MU. Hamacher A, et al. Among authors: kassack mu. BMC Pharmacol. 2006 Sep 15;6:11. doi: 10.1186/1471-2210-6-11. BMC Pharmacol. 2006. PMID: 16978403 Free PMC article.

3

Imidazole-based phosphane gold(I) complexes as potential agents for cancer treatment: synthesis, structural studies and antitumour activity.

Kunz PC, Kassack MU, Hamacher A, Spingler B. Kunz PC, et al. Among authors: kassack mu. Dalton Trans. 2009 Oct 7;(37):7741-7. doi: 10.1039/b902748c. Epub 2009 Jul 30. Dalton Trans. 2009. PMID: 19759948 Free article.

4

NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells.

Meis S, Hamacher A, Hongwiset D, Marzian C, Wiese M, Eckstein N, Royer HD, Communi D, Boeynaems JM, Hausmann R, Schmalzing G, Kassack MU. Meis S, et al. Among authors: kassack mu. J Pharmacol Exp Ther. 2010 Jan;332(1):238-47. doi: 10.1124/jpet.109.157750. Epub 2009 Oct 8. J Pharmacol Exp Ther. 2010. PMID: 19815812

5

Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.

Ebada SS, Schulz B, Wray V, Totzke F, Kubbutat MH, Müller WE, Hamacher A, Kassack MU, Lin W, Proksch P. Ebada SS, et al. Among authors: kassack mu. Bioorg Med Chem. 2011 Aug 1;19(15):4644-51. doi: 10.1016/j.bmc.2011.06.013. Epub 2011 Jul 6. Bioorg Med Chem. 2011. PMID: 21741249

6

Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.

Christiansen E, Urban C, Grundmann M, Due-Hansen ME, Hagesaether E, Schmidt J, Pardo L, Ullrich S, Kostenis E, Kassack M, Ulven T. Christiansen E, et al. J Med Chem. 2011 Oct 13;54(19):6691-703. doi: 10.1021/jm2005699. Epub 2011 Sep 13. J Med Chem. 2011. PMID: 21854074

7

Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides.

Wollinsky B, Ludwig L, Hamacher A, Yu X, Kassack MU, Li SM. Wollinsky B, et al. Among authors: kassack mu. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3866-9. doi: 10.1016/j.bmcl.2012.04.119. Epub 2012 May 4. Bioorg Med Chem Lett. 2012. PMID: 22617493

8

Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties.

Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schröder R, Hudson BD, Milligan G, Cawthorne MA, Kostenis E, Kassack MU, Ulven T. Christiansen E, et al. Among authors: kassack mu. J Med Chem. 2012 Jul 26;55(14):6624-8. doi: 10.1021/jm3002026. Epub 2012 Jul 13. J Med Chem. 2012. PMID: 22724451

9

Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.

Marek L, Hamacher A, Hansen FK, Kuna K, Gohlke H, Kassack MU, Kurz T. Marek L, et al. Among authors: kassack mu. J Med Chem. 2013 Jan 24;56(2):427-36. doi: 10.1021/jm301254q. Epub 2013 Jan 8. J Med Chem. 2013. PMID: 23252603

10

Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.

Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schmidt J, Hansen SV, Hudson BD, Zaibi M, Markussen SB, Hagesaether E, Milligan G, Cawthorne MA, Kostenis E, Kassack MU, Ulven T. Christiansen E, et al. Among authors: kassack mu. J Med Chem. 2013 Feb 14;56(3):982-92. doi: 10.1021/jm301470a. Epub 2013 Jan 22. J Med Chem. 2013. PMID: 23294321

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