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The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.
Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M. Koo SH, et al. Among authors: hedrick s. Nature. 2005 Oct 20;437(7062):1109-11. doi: 10.1038/nature03967. Epub 2005 Sep 7. Nature. 2005. PMID: 16148943
Hepatic glucose sensing via the CREB coactivator CRTC2.
Dentin R, Hedrick S, Xie J, Yates J 3rd, Montminy M. Dentin R, et al. Among authors: hedrick s. Science. 2008 Mar 7;319(5868):1402-5. doi: 10.1126/science.1151363. Science. 2008. PMID: 18323454
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.
Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. Herzig S, et al. Among authors: hedrick s. Nature. 2001 Sep 13;413(6852):179-83. doi: 10.1038/35093131. Nature. 2001. PMID: 11557984
Adipocyte CREB promotes insulin resistance in obesity.
Qi L, Saberi M, Zmuda E, Wang Y, Altarejos J, Zhang X, Dentin R, Hedrick S, Bandyopadhyay G, Hai T, Olefsky J, Montminy M. Qi L, et al. Among authors: hedrick s. Cell Metab. 2009 Mar;9(3):277-86. doi: 10.1016/j.cmet.2009.01.006. Cell Metab. 2009. PMID: 19254572 Free PMC article.
Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity.
Wang Y, Inoue H, Ravnskjaer K, Viste K, Miller N, Liu Y, Hedrick S, Vera L, Montminy M. Wang Y, et al. Among authors: hedrick s. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3087-92. doi: 10.1073/pnas.0914897107. Epub 2010 Jan 26. Proc Natl Acad Sci U S A. 2010. PMID: 20133702 Free PMC article.
279 results